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Stimulation of peroxynitrite catalysis improves insulin sensitivity in high fat diet-fed mice.
Journal article

Stimulation of peroxynitrite catalysis improves insulin sensitivity in high fat diet-fed mice.

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  • 2008-07-02
Published in:
  • The Journal of physiology. - 2008
Animals
Blood Glucose
Catalysis
Dietary Fats
Insulin Resistance
Male
Metalloporphyrins
Mice
Mice, Inbred C57BL
Peroxynitrous Acid
English Peroxynitrite synthesis is increased in insulin resistant animals and humans. Peroxynitirite-induced nitration of insulin signalling proteins impairs insulin action in vitro, but the role of peroxynitrite in the pathogenesis of insulin resistance in vivo is not known. We therefore assessed the effects of a 1-week treatment with the peroxynitrite decomposition catalyst FeTPPS on insulin sensitivity in insulin resistant high fat diet-fed (HFD) and control mice. FeTPPS normalized the fasting plasma glucose and insulin levels (P < 0.01), attenuated the hyperglycaemic response to an intraperitoneal glucose challenge by roughly 50% (P < 0.05), and more than doubled the insulin-induced decrease in plasma glucose levels in HFD-fed mice (P < 0.001). Moreover, FeTPPS restored insulin-stimulated Akt phosphorylation and insulin-stimulated glucose uptake in isolated skeletal muscle in vitro. Stimulation of peroxynitrite catalysis attenuates HFD-induced insulin resistance in mice by restoring insulin signalling and insulin-stimulated glucose uptake in skeletal muscle tissue.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/122807
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