Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study.
- Richard C ENT, Head and Neck Surgery Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland. celine.richard@chuv.ch.
- Courbon G Laboratoire de Biologie des Tissus Ostéoarticulaires, INSERM, U1059 Sainbiose, Université de Lyon, Université Jean Monnet, Faculté de Médecine, Campus Santé Innovation, 42023, Saint-Étienne, France.
- Laroche N Laboratoire de Biologie des Tissus Ostéoarticulaires, INSERM, U1059 Sainbiose, Université de Lyon, Université Jean Monnet, Faculté de Médecine, Campus Santé Innovation, 42023, Saint-Étienne, France.
- Prades JM ENT, Head and Neck Surgery Department, Université de Lyon, Université Jean Monnet, CHU, Hôpital Nord, 42055, Saint-Étienne, France.
- Vico L Laboratoire de Biologie des Tissus Ostéoarticulaires, INSERM, U1059 Sainbiose, Université de Lyon, Université Jean Monnet, Faculté de Médecine, Campus Santé Innovation, 42023, Saint-Étienne, France.
- Malaval L Laboratoire de Biologie des Tissus Ostéoarticulaires, INSERM, U1059 Sainbiose, Université de Lyon, Université Jean Monnet, Faculté de Médecine, Campus Santé Innovation, 42023, Saint-Étienne, France.
- 2017-07-08
Published in:
- Scientific reports. - 2017
Abortion, Spontaneous
Calcification, Physiologic
Ear, Inner
Ear, Middle
Female
Fetal Death
Fetal Development
Fetus
Gestational Age
Hearing
Humans
Osteogenesis
Postural Balance
Pregnancy
X-Ray Microtomography
English
Little is known about middle and inner ear development during the second and third parts of human fetal life. Using ultra-high resolution Microcomputed Tomography coupled with bone histology, we performed the first quantitative middle and inner ear ossification/mineralization evaluation of fetuses between 17 and 39 weeks of gestational age. We show distinct ossification paces between ossicles, with a belated development of the stapes. A complete cochlear bony covering is observed within the time-frame of the onset of hearing, whereas distinct time courses of ossification for semicircular canal envelopes are observed in relation to the start of vestibular functions. The study evidences a spatio-temporal relationship between middle and inner ear structure development and the onset of hearing and balance, critical senses for the fetal adaptation to birth.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1038/s41598-017-05151-0
- PMID 28684743
- Persistent URL
- https://sonar.ch/global/documents/123138
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