Back
Catechin solubilization by spontaneous hydrogen bonding with poly(ethylene glycol) for dry eye therapeutics.
Journal article

Catechin solubilization by spontaneous hydrogen bonding with poly(ethylene glycol) for dry eye therapeutics.

  • Shim W Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
  • Kim CE T2B Infrastructure Center for Ocular Disease, Busan Paik Hospital, Busan, Republic of Korea.
  • Lee M Tissue Engineering, Biofabrication Laboratory, Institute for Biomechanics, ETH Zürich, Otto-Stern-Weg 7, 8093 Zürich, Switzerland.
  • Lee SH Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
  • Park J Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
  • Do M Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
  • Yang J T2B Infrastructure Center for Ocular Disease, Busan Paik Hospital, Busan, Republic of Korea; Department of Ophthalmology, Inje University, College of Medicine, Busan Paik Hospital, Busan, Republic of Korea.
  • Lee H Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. Electronic address: haeshin@kaist.ac.kr.
Show more…
  • 2019-05-24
Published in:
  • Journal of controlled release : official journal of the Controlled Release Society. - 2019
Catechin
Catechol
Hydrogen bond
Poly(ethylene glycol) (PEG)
Polyphenol
Animals
Catechin
Dry Eye Syndromes
Freeze Drying
Hydrogen Bonding
Male
Mice
Nanoparticles
Ophthalmic Solutions
Polyethylene Glycols
Solubility
English Catechin exhibits various pharmacological effects, yet its poor aqueous solubility limits its clinical use. Here, we investigate a facile catechin solubilization method via spontaneous hydrogen bonding between catechin and poly(ethylene glycol) (PEG). The method is extremely simple in that mixing PEG with catechin followed by lyophilization completely converts insoluble catechin to soluble PEG/catechin nanoscale complexes. This solubilized catechin formulation is useful for preparing eyedrop medicine, and we demonstrate that the solubilized catechin exhibits therapeutic effect upon dry eye diseases.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/123196
Statistics
Document views: 20 File downloads: