Liposome-associated retinoic acid. Increased in vitro antiproliferative effects on neoplastic cells.
- Nastruzzi C Institut fur Polymere, ETH-Zentrum, Zurich, Switzerland.
- Walde P
- Menegatti E
- Gambari R
- 1990-01-01
Published in:
- FEBS letters. - 1990
Animals
Cell Division
Drug Carriers
Freeze Fracturing
Humans
Leukemia, Erythroblastic, Acute
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Liposomes
Melanoma
Mice
Microscopy, Electron
Phosphatidylcholines
Tretinoin
Tumor Cells, Cultured
English
The activity of liposome-associated retinoic acid was analyzed on in vitro cultured tumor cell lines and compared to the antiproliferative effects of free retinoic acid. It was found that liposome-associated retinoic acid is about 300 times more active than free retinoic acid in inhibiting in vitro cell growth of leukemic and melanoma cell lines. An increased activity of retinoic acid (10-20 times) was also obtained after premixing of this compound with empty liposomes, demonstrating that the retinoic acid efficiently interacts with liposomes which may facilitate solubility and cell uptake of retinoids.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1016/0014-5793(90)80030-m
- PMID 2294018
- Persistent URL
- https://sonar.ch/global/documents/123730
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