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Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients.

  • Stemler J Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
  • Bruns C Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
  • Mellinghoff SC Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
  • Alakel N Department of Internal Medicine I, University Hospital of Dresden, 01307 Dresden, Germany.
  • Akan H Hematology Clinical Research Unit, Cebeci Hospital, Ankara University Faculty of Medicine, 06100 Ankara, Turkey.
  • Ananda-Rajah M Dept of Infectious Diseases and General Medical Unit, Alfred Health & Central Clinical School, Monash University, Melbourne 3004, Australia.
  • Auberger J Onkologische Schwerpunktpraxis Freilassing, 83395 Freilassing, Germany.
  • Bojko P Department of Hematology and Oncology, Red Cross Hospital Munich, 80634 Munich, Germany.
  • Chandrasekar PH Division of Infectious Diseases, Wayne State University School of Medicine, Karmanos Cancer Center, Detroit, WI 4100, USA.
  • Chayakulkeeree M Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
  • Cozzi JA Hematology Department, Hospital Provincial Del Centenario, Rosario 2000, Argentina.
  • de Kort EA Department of Hematology, Radboud University Medical Center, 6500 Nijmegen, The Netherlands.
  • Groll AH Infectious Disease Research Program, Center for Bone Marrow Transplantation and, Department of Pediatric Hematology and Oncology, University Children's Hospital, 48149 Münster, Germany.
  • Heath CH Department of Microbiology (PathWest Laboratory Medicine, WA, FSH Network), Perth 6000, Australia.
  • Henze L Department of Medicine, Clinic III-Hematology, Oncology, Palliative Medicine, Rostock University Medical Center, 18057 Rostock, Germany.
  • Hernandez Jimenez M Head of the Bone Marrow Unit, Hospital City Dr. Enrique Tejera, Valencia 2001, Venezuela.
  • Kanj SS Division of Infectious Diseases, Infection Control Program, Antimicrobial Stewardship Program, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.
  • Khanna N Division of Infection Diseases and Hospital Epidemiology, University Hospital of Basel, 4031 Basel, Switzerland.
  • Koldehoff M Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
  • Lee DG Division of Infectious Diseases, Department of Internal Medicine, Catholic Hematology Hospital & Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
  • Mager A Department of Diagnostic and Interventional Radiology, University of Cologne, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany.
  • Marchesi F Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi, 53 00144 Rome, Italy.
  • Martino-Bufarull R Servei d'Hematologia Clinica, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
  • Nucci M Department of Internal Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.
  • Oksi J Department of Infectious Diseases, Turku University Hospital and University of Turku, 20521 Turku, Finland.
  • Pagano L Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico A. Gemelli -IRCCS, 00169 Rome, Italy.
  • Phillips B Leeds Children's Hospital, Leeds General Infirmary, Leeds Teaching Hospitals, NHS Trust, Leeds LS1 3EX, UK.
  • Prattes J Department of Internal Medicine, Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, 8036 Graz, Austria.
  • Pyrpasopoulou A Infectious Diseases Unit, Hippokration Hospital, 54642 Thessaloniki, Greece.
  • Rabitsch W Department of Internal Medicine I, Bone Marrow Transplant-Unit, Medical University of Vienna, 1090 Vienna, Austria.
  • Schalk E Department of Hematology and Oncology, Otto-von-Guericke University Magdeburg, Medical Center, 39120 Magdeburg, Germany.
  • Schmidt-Hieber M Medizinische Klinik, Carl-Thiem-Klinikum Cottbus, 03048 Cottbus, Germany.
  • Sidharthan N Department of Clinical Haematology, Amrita Institute of Medical Sciences, Kochi 682041, India.
  • Soler-Palacín P Pediatric Infectious Diseases and Immunodeficiencies Unit. Vall d'Hebron Barcelona Hospital Campus, 08035 Barcelona, Spain.
  • Stern A Infectious Diseases institute, Rambam Health Care Campus, Haifa 3109601, Israel.
  • Weinbergerová B Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital Brno, 62500 Brno, Czech Republic.
  • El Zakhem A Division of Infectious Diseases, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.
  • Cornely OA Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
  • Koehler P Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
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  • 2020-03-19
Published in:
  • Journal of fungi (Basel, Switzerland). - 2020
antifungal prophylaxis
infection in hematology
invasive aspergillosis
English Baseline chest computed tomography (BCT) in high-risk hematology patients allows for the early diagnosis of invasive pulmonary aspergillosis (IPA). The distribution of BCT implementation in hematology departments and impact on outcome is unknown. A web-based questionnaire was designed. International scientific bodies were invited. The estimated numbers of annually treated hematology patients, chest imaging timepoints and techniques, IPA rates, and follow-up imaging were assessed. In total, 142 physicians from 43 countries participated. The specialties included infectious diseases (n = 69; 49%), hematology (n = 68; 48%), and others (n = 41; 29%). BCT was performed in 57% (n = 54) of 92 hospitals. Upon the diagnosis of malignancy or admission, 48% and 24% performed BCT, respectively, and X-ray was performed in 48% and 69%, respectively. BCT was more often used in hematopoietic cell transplantation and in relapsed acute leukemia. European centers performed BCT in 59% and non-European centers in 53%. Median estimated IPA rate was 8% and did not differ between BCT (9%; IQR 5-15%) and non-BCT centers (7%; IQR 5-10%) (p = 0.69). Follow-up computed tomography (CT) for IPA was performed in 98% (n = 90) of centers. In high-risk hematology patients, baseline CT is becoming a standard-of-care. Chest X-ray, while inferior, is still widely used. Randomized, controlled trials are needed to investigate the impact of BCT on patient outcome.
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  • English
Open access status
gold
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https://sonar.ch/global/documents/123818
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