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Journal article

Chromatin movement in the maintenance of genome stability.

  • Dion V Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
  • Gasser SM
  • 2013-03-19
Published in:
  • Cell. - 2013
Animals
Chromatin
DNA
DNA Damage
DNA Repair
Genomic Instability
Humans
Movement
Transcription, Genetic
English Mechanistic analyses based on improved imaging techniques have begun to explore the biological implications of chromatin movement within the nucleus. Studies in both prokaryotes and eukaryotes have shed light on what regulates the mobility of DNA over long distances. Interestingly, in eukaryotes, genomic loci increase their movement in response to double-strand break induction. Break mobility, in turn, correlates with the efficiency of repair by homologous recombination. We review here the source and regulation of DNA mobility and discuss how it can both contribute to and jeopardize genome stability.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/124234
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