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Reproducibility of functional connectivity and graph measures based on the phase lag index (PLI) and weighted phase lag index (wPLI) derived from high resolution EEG.

  • Hardmeier M Department of Neurology, Hospital of the University of Basel, Basel, Switzerland.
  • Hatz F Department of Neurology, Hospital of the University of Basel, Basel, Switzerland.
  • Bousleiman H Department of Neurology, Hospital of the University of Basel, Basel, Switzerland; Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland.
  • Schindler C Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland.
  • Stam CJ Department of Clinical Neurophysiology and Magnetoencephalography, VU University Medical Center, Amsterdam, The Netherlands.
  • Fuhr P Department of Neurology, Hospital of the University of Basel, Basel, Switzerland.
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  • 2014-10-07
Published in:
  • PloS one. - 2014
Adult
Electroencephalography
Female
Humans
Male
Middle Aged
Nerve Net
Reproducibility of Results
Time Factors
Young Adult
English Functional connectivity (FC) and graph measures provide powerful means to analyze complex networks. The current study determines the inter-subject-variability using the coefficient of variation (CoV) and long-term test-retest-reliability (TRT) using the intra-class correlation coefficient (ICC) in 44 healthy subjects with 35 having a follow-up at years 1 and 2. FC was estimated from 256-channel-EEG by the phase-lag-index (PLI) and weighted PLI (wPLI) during an eyes-closed resting state condition. PLI quantifies the asymmetry of the distribution of instantaneous phase differences of two time-series and signifies, whether a consistent non-zero phase lag exists. WPLI extends the PLI by additionally accounting for the magnitude of the phase difference. Signal-space global and regional PLI/wPLI and weighted first-order graph measures, i.e. normalized clustering coefficient (gamma), normalized average path length (lambda), and the small-world-index (SWI) were calculated for theta-, alpha1-, alpha2- and beta-frequency bands. Inter-subject variability of global PLI was low to moderate over frequency bands (0.12
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  • English
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gold
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https://sonar.ch/global/documents/124313
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