Journal article
Associations of Novel and Traditional Vascular Biomarkers of Arterial Stiffness: Results of the SAPALDIA 3 Cohort Study.
- Endes S Department of Sport, Exercise and Health, Div. Sports and Exercise Medicine, University of Basel, Switzerland.
- Caviezel S Swiss Tropical and Public Health Institute, Basel, Switzerland.
- Schaffner E Swiss Tropical and Public Health Institute, Basel, Switzerland.
- Dratva J Swiss Tropical and Public Health Institute, Basel, Switzerland.
- Schindler C Swiss Tropical and Public Health Institute, Basel, Switzerland.
- Künzli N Swiss Tropical and Public Health Institute, Basel, Switzerland.
- Bachler M Biomedical Systems, Health & Environment Department, AIT Austrian Institute of Technology GmbH, Vienna, Austria.
- Wassertheurer S Biomedical Systems, Health & Environment Department, AIT Austrian Institute of Technology GmbH, Vienna, Austria.
- Probst-Hensch N Swiss Tropical and Public Health Institute, Basel, Switzerland.
- Schmidt-Trucksäss A Department of Sport, Exercise and Health, Div. Sports and Exercise Medicine, University of Basel, Switzerland.
- 2016-09-30
Published in:
- PloS one. - 2016
English
BACKGROUND AND OBJECTIVES
There is a lack of evidence concerning associations between novel parameters of arterial stiffness as cardiovascular risk markers and traditional structural and functional vascular biomarkers in a population-based Caucasian cohort. We examined these associations in the second follow-up of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA 3).
METHODS
Arterial stiffness was measured oscillometrically by pulse wave analysis to derive the cardio-ankle vascular index (CAVI), brachial-ankle (baPWV) and aortic pulse wave velocity (aPWV), and amplitude of the forward and backward wave. Carotid ultrasonography was used to measure carotid intima-media thickness (cIMT) and carotid lumen diameter (LD), and to derive a distensibility coefficient (DC). We used multivariable linear regression models adjusted for several potential confounders for 2,733 people aged 50-81 years.
RESULTS
CAVI, aPWV and the amplitude of the forward and backward wave were significant predictors of cIMT (p < 0.001). All parameters were significantly associated with LD (p < 0.001), with aPWV and the amplitude of the forward wave explaining the highest proportion of variance (2%). Only CAVI and baPWV were significant predictors of DC (p < 0.001), explaining more than 0.3% of the DC variance.
CONCLUSION
We demonstrated that novel non-invasive oscillometric arterial stiffness parameters are differentially associated with specific established structural and functional local stiffness parameters. Longitudinal studies are needed to follow-up on these cross-sectional findings and to evaluate their relevance for clinical phenotypes.
There is a lack of evidence concerning associations between novel parameters of arterial stiffness as cardiovascular risk markers and traditional structural and functional vascular biomarkers in a population-based Caucasian cohort. We examined these associations in the second follow-up of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA 3).
METHODS
Arterial stiffness was measured oscillometrically by pulse wave analysis to derive the cardio-ankle vascular index (CAVI), brachial-ankle (baPWV) and aortic pulse wave velocity (aPWV), and amplitude of the forward and backward wave. Carotid ultrasonography was used to measure carotid intima-media thickness (cIMT) and carotid lumen diameter (LD), and to derive a distensibility coefficient (DC). We used multivariable linear regression models adjusted for several potential confounders for 2,733 people aged 50-81 years.
RESULTS
CAVI, aPWV and the amplitude of the forward and backward wave were significant predictors of cIMT (p < 0.001). All parameters were significantly associated with LD (p < 0.001), with aPWV and the amplitude of the forward wave explaining the highest proportion of variance (2%). Only CAVI and baPWV were significant predictors of DC (p < 0.001), explaining more than 0.3% of the DC variance.
CONCLUSION
We demonstrated that novel non-invasive oscillometric arterial stiffness parameters are differentially associated with specific established structural and functional local stiffness parameters. Longitudinal studies are needed to follow-up on these cross-sectional findings and to evaluate their relevance for clinical phenotypes.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1371/journal.pone.0163844
- PMID 27685325
- Persistent URL
- https://sonar.ch/global/documents/124458
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