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Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper.
Journal article

Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper.

  • Palmer E Department of Nephrology and Biomedicine, Laboratory of Transplantation Immunology, University Hospital Basel, Basel, Switzerland. ed.palmer@unibas.ch
  • Naeher D
  • 2009-01-20
Published in:
  • Nature reviews. Immunology. - 2009
Animals
Autoantigens
Humans
Lymphopoiesis
Major Histocompatibility Complex
Mice
Receptors, Antigen, T-Cell
T-Cell Antigen Receptor Specificity
T-Lymphocytes
Thymus Gland
English The affinity of the T-cell receptor (TCR) for self antigen is the basis for the selection of a useful (MHC-restricted) and safe (self-tolerant) T-cell repertoire. However, it has been difficult to understand how thymocytes measure ligand affinity and translate this signal into a cellular response. In this Opinion article, we propose a new model that describes how the TCR discriminates between low- and high-affinity ligands, which is based on the duration of TCR-ligand interactions and a 'zipper' mechanism that mediates the interaction of the TCR and co-receptor molecules to initiate negative-selection signalling.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/12455
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