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Circulating Tumor Cell-Neutrophil Tango along the Metastatic Process.
Journal article

Circulating Tumor Cell-Neutrophil Tango along the Metastatic Process.

  • Saini M Department of Biomedicine, Cancer Metastasis Lab, University of Basel and University Hospital Basel, Basel, Switzerland.
  • Szczerba BM Department of Biomedicine, Cancer Metastasis Lab, University of Basel and University Hospital Basel, Basel, Switzerland.
  • Aceto N Department of Biomedicine, Cancer Metastasis Lab, University of Basel and University Hospital Basel, Basel, Switzerland. Nicola.Aceto@unibas.ch.
  • 2019-09-19
Published in:
  • Cancer research. - 2019
Animals
Antineoplastic Agents, Immunological
Cell Communication
Costimulatory and Inhibitory T-Cell Receptors
Disease Models, Animal
Disease Progression
Humans
Neoplasm Metastasis
Neoplasms
Neoplastic Cells, Circulating
Neutrophil Infiltration
Neutrophils
T-Lymphocytes
English The crosstalk between cancer cells and the immune system is crucial for disease progression and its therapeutic targeting is providing exciting results, in particular with newly developed immune checkpoint inhibitors. Current approaches primarily focus on cellular interactions occurring between tumor cells and T lymphocytes; however, recent data highlight a crucial role of neutrophils in support of tumor progression and suggest yet unexplored treatment opportunities. In this review, we summarize the current understanding of those interactions that occur between neutrophils and cancer cells, focusing on both protumor and antitumor activities of neutrophils at different stages of cancer progression. These include infiltration of neutrophils into the primary tumor, their interactions with circulating tumor cells (CTC) within the bloodstream, and their involvement in the establishment of a metastatic niche. Additionally, we discuss how further investigation of CTCs and their interacting immune cell partners may point towards novel immune checkpoint inhibition strategies and provide new insights on the efficacy of already existing immunotherapies.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/124742
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