Journal article
Gray matters!--mapping the transition to psychosis.
- Borgwardt S Department of Psychiatry, University of Basel, Basel, Switzerland. sborgwardt@uhbs.ch
- McGuire P
- Fusar-Poli P
- 2011-09-28
Published in:
- Schizophrenia research. - 2011
Brain
Brain Mapping
Cross-Sectional Studies
Humans
Longitudinal Studies
Neuroimaging
Psychotic Disorders
PubMed
English
Despite many neuroimaging studies on schizophrenia showing brain abnormalities the exact time course of their occurrence is unknown. Studies of gray matter are a powerful tool in biological psychiatry and provide an unprecedented opportunity for brain structure investigations. Here we compared cross-sectional and longitudinal structural neuroimaging studies distinguishing high-risk subjects developing psychosis from those who did not. These investigations on gray matter volumes in the prodromal phase potentially identify core structural markers of impending psychoses and clarify dynamic changes underlying the transition. Subjects at high risk of psychosis show qualitatively similar albeit less severe gray matter abnormalities as patients with psychosis.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.schres.2011.08.021
- PMID 21943556
- Persistent URL
- https://sonar.ch/global/documents/12489
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