Impact of Growth Hormone on Cystatin C.
- Sze L Division of Endocrinology and Diabetes, Kantonsspital, St. Gallen, Frauenfeld, Switzerland ; Division of Endocrinology and Diabetes, Kantonsspital, St. Gallen, Frauenfeld, Switzerland.
- Bernays RL Department of Neurosurgery, University Hospital, Frauenfeld, Switzerland ; Department of Neurosurgery, Clinic Hirslanden, Zurich, Frauenfeld, Switzerland.
- Zwimpfer C Division of Endocrinology and Diabetes, Kantonsspital, St. Gallen, Frauenfeld, Switzerland.
- Wiesli P Department of Internal Medicine, Kantonsspital Frauenfeld, Frauenfeld, Switzerland.
- Brändle M Division of Endocrinology and Diabetes, Kantonsspital, St. Gallen, Frauenfeld, Switzerland.
- Schmid C Division of Endocrinology and Diabetes, Kantonsspital, St. Gallen, Frauenfeld, Switzerland.
- 2013-12-19
Published in:
- Nephron extra. - 2013
English
BACKGROUND
Cystatin C (CysC) is an alternative marker to creatinine for estimation of the glomerular filtration rate (GFR). Hormones such as thyroid hormones and glucocorticoids are known to have an impact on CysC. In this study, we examined the effect of growth hormone (GH) on CysC in patients with acromegaly undergoing transsphenoidal surgery.
METHODS
Creatinine, CysC, GH and insulin-like growth factor-1 (IGF-1) were determined in 24 patients with acromegaly before and following transsphenoidal surgery. Estimated GFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration formula.
RESULTS
In all patients, surgical debulking resulted in decreased clinical disease activity and declining GH/IGF-1 levels. Postoperatively, biochemical cure was documented in 20 out of 24 patients. Creatinine levels (mean ± SEM) increased from 72 ± 3 to 80 ± 3 µmol/l (p = 0.0004) and concurrently, estimated GFR decreased from 99 ± 3 to 91 ± 3 ml/min (p = 0.0008). In contrast to creatinine, CysC levels decreased from 0.72 ± 0.02 to 0.68 ± 0.02 mg/l (p = 0.0008).
CONCLUSIONS
Our study provides strong evidence for discordant effects of GH on creatinine and CysC in patients with acromegaly undergoing transsphenoidal surgery, thus identifying another hormone that influences CysC independent of renal function.
Cystatin C (CysC) is an alternative marker to creatinine for estimation of the glomerular filtration rate (GFR). Hormones such as thyroid hormones and glucocorticoids are known to have an impact on CysC. In this study, we examined the effect of growth hormone (GH) on CysC in patients with acromegaly undergoing transsphenoidal surgery.
METHODS
Creatinine, CysC, GH and insulin-like growth factor-1 (IGF-1) were determined in 24 patients with acromegaly before and following transsphenoidal surgery. Estimated GFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration formula.
RESULTS
In all patients, surgical debulking resulted in decreased clinical disease activity and declining GH/IGF-1 levels. Postoperatively, biochemical cure was documented in 20 out of 24 patients. Creatinine levels (mean ± SEM) increased from 72 ± 3 to 80 ± 3 µmol/l (p = 0.0004) and concurrently, estimated GFR decreased from 99 ± 3 to 91 ± 3 ml/min (p = 0.0008). In contrast to creatinine, CysC levels decreased from 0.72 ± 0.02 to 0.68 ± 0.02 mg/l (p = 0.0008).
CONCLUSIONS
Our study provides strong evidence for discordant effects of GH on creatinine and CysC in patients with acromegaly undergoing transsphenoidal surgery, thus identifying another hormone that influences CysC independent of renal function.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1159/000356464
- PMID 24348508
- Persistent URL
- https://sonar.ch/global/documents/125564
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