Heterogeneous growth-induced prestrain in the heart.
- Genet M Department of Surgery, School of Medicine, University of California at San Francisco, USA; Institute for Biomedical Engineering, University and ETH Zürich, Switzerland. Electronic address: genet@biomed.ee.ethz.ch.
- Rausch MK Department of Mechanical Engineering, Stanford University, CA, USA.
- Lee LC Department of Surgery, School of Medicine, University of California at San Francisco, USA; Department of Mechanical Engineering, Michigan State University, MI, USA.
- Choy S Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, USA.
- Zhao X Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, USA.
- Kassab GS Department of Mechanical Engineering, Michigan State University, MI, USA; Department of Cellular and Integrative Physiology, Indiana University-Purdue University Indianapolis, USA; Department of Surgery, Indiana University-Purdue University Indianapolis, USA.
- Kozerke S Institute for Biomedical Engineering, University and ETH Zürich, Switzerland.
- Guccione JM Department of Surgery, School of Medicine, University of California at San Francisco, USA.
- Kuhl E Department of Mechanical Engineering, Stanford University, CA, USA; Department of Bioengineering, Stanford University, CA, USA; Department of Cardiothoracic Surgery, Stanford University, CA, USA.
- 2015-04-28
Published in:
- Journal of biomechanics. - 2015
Finite element method
Finite strain
Opening angle
Patient-specific modeling
Prestrain
Residual stress
Animals
Arteries
Biomechanical Phenomena
Female
Finite Element Analysis
Heart Ventricles
Humans
Male
Models, Animal
Models, Cardiovascular
Stress, Mechanical
Swine
Ventricular Function
English
Even when entirely unloaded, biological structures are not stress-free, as shown by Y.C. Fung׳s seminal opening angle experiment on arteries and the left ventricle. As a result of this prestrain, subject-specific geometries extracted from medical imaging do not represent an unloaded reference configuration necessary for mechanical analysis, even if the structure is externally unloaded. Here we propose a new computational method to create physiological residual stress fields in subject-specific left ventricular geometries using the continuum theory of fictitious configurations combined with a fixed-point iteration. We also reproduced the opening angle experiment on four swine models, to characterize the range of normal opening angle values. The proposed method generates residual stress fields which can reliably reproduce the range of opening angles between 8.7±1.8 and 16.6±13.7 as measured experimentally. We demonstrate that including the effects of prestrain reduces the left ventricular stiffness by up to 40%, thus facilitating the ventricular filling, which has a significant impact on cardiac function. This method can improve the fidelity of subject-specific models to improve our understanding of cardiac diseases and to optimize treatment options.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1016/j.jbiomech.2015.03.012
- PMID 25913241
- Persistent URL
- https://sonar.ch/global/documents/127079
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