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Inflammasomes of the intestinal epithelium.
Journal article

Inflammasomes of the intestinal epithelium.

  • Sellin ME Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland. Electronic address: msellin@micro.biol.ethz.ch.
  • Maslowski KM Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
  • Maloy KJ Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.
  • Hardt WD Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland. Electronic address: hardt@micro.biol.ethz.ch.
  • 2015-07-14
Published in:
  • Trends in immunology. - 2015
NLRP3
caspase-1
extrusion
innate immunity
intestinal epithelial cell (IEC)
mucus
Animals
Humans
Immunity, Mucosal
Inflammasomes
Intestinal Mucosa
English While the functional importance of inflammasomes in blood-derived cell types is well established, it remains poorly understood how inflammasomes in nonhematopoietic cells contribute to mucosal immunity. Recent studies have revealed functional roles of inflammasomes - particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) - within epithelial cells of the gut in mucosal immune defense, inflammation, and tumorigenesis. Here, we review and discuss these findings in the broader context of tissue compartment-specific mucosal immunity. We propose several models whereby activities of the intestinal epithelial inflammasomes converge on mechanisms to remove compromised epithelial cells, maintain host-microbiota mutualism, and communicate with immune cells of the underlying lamina propria.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/127119
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