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Altered functional connectivity of the language network in ASD: role of classical language areas and cerebellum.
Journal article

Altered functional connectivity of the language network in ASD: role of classical language areas and cerebellum.

  • Verly M Department of Neurosciences, Exp ORL, Catholic University of Leuven, Leuven, Belgium ; Department of Radiology, University Hospitals of the Catholic University of Leuven, Leuven, Belgium.
  • Verhoeven J Department of Radiology, University Hospitals of the Catholic University of Leuven, Leuven, Belgium ; Leuven Autism Research (LAURES) Consortium, Catholic University of Leuven, Leuven, Belgium ; Department of Pediatrics, University Hospitals of the Catholic University of Leuven, Leuven, Belgium.
  • Zink I Department of Neurosciences, Exp ORL, Catholic University of Leuven, Leuven, Belgium.
  • Mantini D Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK ; Department of Heath Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland ; Department of Neurosciences, Laboratory for Neuro- and Psychophysiology, KU Leuven, 3000 Leuven, Belgium.
  • Peeters R Department of Radiology, University Hospitals of the Catholic University of Leuven, Leuven, Belgium.
  • Deprez S Department of Radiology, University Hospitals of the Catholic University of Leuven, Leuven, Belgium.
  • Emsell L Department of Radiology, University Hospitals of the Catholic University of Leuven, Leuven, Belgium.
  • Boets B Leuven Autism Research (LAURES) Consortium, Catholic University of Leuven, Leuven, Belgium ; Parenting and Special Education Research Unit, Catholic University of Leuven, Leuven, Belgium ; Department of Child and Adolescent Psychiatry, University Hospitals of the Catholic University of Leuven, Leuven, Belgium.
  • Noens I Leuven Autism Research (LAURES) Consortium, Catholic University of Leuven, Leuven, Belgium ; Parenting and Special Education Research Unit, Catholic University of Leuven, Leuven, Belgium ; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, USA.
  • Steyaert J Leuven Autism Research (LAURES) Consortium, Catholic University of Leuven, Leuven, Belgium ; Department of Child and Adolescent Psychiatry, University Hospitals of the Catholic University of Leuven, Leuven, Belgium ; Department of Clinical Genetics, University of Maastricht, Maastricht, The Netherlands.
  • Lagae L Department of Pediatrics, University Hospitals of the Catholic University of Leuven, Leuven, Belgium.
  • De Cock P Leuven Autism Research (LAURES) Consortium, Catholic University of Leuven, Leuven, Belgium ; Department of Pediatrics, University Hospitals of the Catholic University of Leuven, Leuven, Belgium ; Center for Developmental Disabilities, University Hospitals of the Catholic University of Leuven, Leuven, Belgium.
  • Rommel N Department of Neurosciences, Exp ORL, Catholic University of Leuven, Leuven, Belgium.
  • Sunaert S Department of Radiology, University Hospitals of the Catholic University of Leuven, Leuven, Belgium ; Leuven Autism Research (LAURES) Consortium, Catholic University of Leuven, Leuven, Belgium.
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  • 2014-02-26
Published in:
  • NeuroImage. Clinical. - 2014
Autism spectrum disorders
Cerebellum
Language function
Resting state fMRI
Adolescent
Autism Spectrum Disorder
Cerebellum
Connectome
Female
Humans
Language
Language Disorders
Magnetic Resonance Imaging
Male
Nerve Net
Neural Pathways
Reproducibility of Results
Sensitivity and Specificity
English The development of language, social interaction and communicative skills is remarkably different in the child with autism spectrum disorder (ASD). Atypical brain connectivity has frequently been reported in this patient population. However, the neural correlates underlying their disrupted language development and functioning are still poorly understood. Using resting state fMRI, we investigated the functional connectivity properties of the language network in a group of ASD patients with clear comorbid language impairment (ASD-LI; N = 19) and compared them to the language related connectivity properties of 23 age-matched typically developing children. A verb generation task was used to determine language components commonly active in both groups. Eight joint language components were identified and subsequently used as seeds in a resting state analysis. Interestingly, both the interregional and the seed-based whole brain connectivity analysis showed preserved connectivity between the classical intrahemispheric language centers, Wernicke's and Broca's areas. In contrast however, a marked loss of functional connectivity was found between the right cerebellar region and the supratentorial regulatory language areas. Also, the connectivity between the interhemispheric Broca regions and modulatory control dorsolateral prefrontal region was found to be decreased. This disruption of normal modulatory control and automation function by the cerebellum may underlie the abnormal language function in children with ASD-LI.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/127123
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