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High association of MOG-IgG antibodies in children with bilateral optic neuritis.
Journal article

High association of MOG-IgG antibodies in children with bilateral optic neuritis.

  • Wendel EM Department of Pediatrics, Olgahospital, Klinikum, Stuttgart, Germany.
  • Baumann M Division of Pediatric Neurology, Department of Pediatrics I, Medical University of Innsbruck, Austria.
  • Barisic N Department of Pediatrics, Clinical Medical Center Zagreb, University of Zagreb Medical School, Croatia.
  • Blaschek A Department of Pediatric Neurology, Dr. von Hauner Children's Hospital, Ludwig-Maximillian-Universität Munich, Germany.
  • Coelho de Oliveira Koch E Division of Pediatric Neurology, Department of Pediatrics, Medical University of Geneva, Switzerland.
  • Della Marina A Department of Neuropediatrics, Developmental Neurology and Social Pediatrics, Children's Hospital, University of Duisburg-Essen, Germany.
  • Diepold K Division of Pediatric Neurology, Department of Pediatrics, Hospital Kassel, Germany.
  • Hackenberg A Department of Pediatric Neurology, University Children's Hospital, Zürich, Switzerland.
  • Hahn A Division of Pediatric Neurology, Department of Pediatrics, Medical University Giessen, Germany.
  • von Kalle T Department of Pediatric Radiology, Olgahospital, Klinikum Stuttgart, Germany.
  • Karenfort M Department of Pediatrics, Neonatology and Pediatric Cardiology, Children's Hospital, Heinrich-Heine-University, Düsseldorf, Germany.
  • Kornek B Department of Neurology, Medical University Vienna, Austria.
  • Lechner C Division of Pediatric Neurology, Department of Pediatrics I, Medical University of Innsbruck, Austria.
  • Leiz S Division of Pediatric Neurology, Department of Pediatrics, Klinikum Dritter Orden, Munich, Germany.
  • Merkenschlager A Division of Pediatric Neurology, Department of Pediatrics, Medical University of Leipzig, Germany.
  • Nosadini M Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Italy.
  • Sartori S Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Italy.
  • Schanda K Clinical Department of Neurology, Medical University of Innsbruck, Austria.
  • Schimmel M Division of Pediatric Neurology, Children's Hospital, Medical University of Augsburg, Germany.
  • Seemann L Department of Pediatric Neurology, Children's Hospital DRK Siegen, Germany.
  • Tüngler V Division of Pediatric Neurology, Department of Pediatrics, Medical University Carl Gustav Carus, Dresden, Germany.
  • Waltz S Department of Pediatric Neurology, Children's Hospital Amsterdamer Straße, Cologne, Germany.
  • Wegener-Panzer A Department of Pediatric Radiology, Children's Hospital Datteln, University Witten/Herdecke, Germany.
  • Wiegand G Division of Pediatric Neurology, Department of Pediatrics, Asklepios Klinik Nord, Heidberg/Hamburg, Germany.
  • Reindl M Clinical Department of Neurology, Medical University of Innsbruck, Austria.
  • Rostásy K Department of Pediatric Neurology, Children's Hospital Datteln, University Witten/Herdecke, Germany. Electronic address: k.rostasy@kinderklinik-datteln.de.
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  • 2020-04-25
Published in:
  • European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. - 2020
English BACKGROUND
Bilateral optic neuritis (bilON) is a rare clinical presentation often thought to be associated with relapsing disorders such as neuromyelitis optica spectrum disorders (NMOSD) or multiple sclerosis (MS).


OBJECTIVE
To characterize the clinical, radiological phenotype and antibody status of children presenting with bilON.


MATERIAL AND METHODS
Retrospective multicenter study on children with bilON age <18 years with a first episode aquired demyelinating syndrome (ADS), cMRI, AQP4- and serum MOG-antibody status and follow-up data were collected.


RESULTS
30 patients (f:m = 15:15, median age 8.0y) with bilON met the inclusion criteria. 22/30 (73%) were MOG-positive (median: 1:1280, range: 1:160-1:1520). No patient showed AQP4-abs. 4/30 patients (13%), all with high MOG-abs titers, had recurrent episodes. No patient developed MS. Improvement after IVMP was observed in most patients (26/30; 87%). Outcome was favorable with no sequelae in 22/30 patients. Serial MOG-abs titers tested in 15/22 patients decreased to a median of 1:160 (range: 0-1:640) over a period of 31 months (range: 2-141 months) in 14/15 (93%) patients. MR imaging showed a predominantly anterior affection of the visual system in seropositive patients with bilateral intraorbital lesions in 68% (15/22), compared to 25% in MOG-negative patients (2/8).


CONCLUSION
Pediatric bilON is associated with high MOG-abs titers in combination with anterior involvement of the visual system. Despite severe loss of vision, the majority of patients shows distinct recovery after IVMP.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/127460
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