Journal article
Sex differences in presentation, management, and prognosis of patients with non-small cell lung carcinoma.
- de Perrot M Thoracic Surgery Unit and the Division of Anesthesiology, University Hospital of Geneva, and the Geneva Cancer Registry, Geneva, Switzerland.
- Licker M
- Bouchardy C
- Usel M
- Robert J
- Spiliopoulos A
- 1999-12-29
Published in:
- The Journal of thoracic and cardiovascular surgery. - 2000
Adult
Aged
Aged, 80 and over
Bronchoscopy
Carcinoma, Non-Small-Cell Lung
Chi-Square Distribution
Female
Humans
Lung Neoplasms
Male
Middle Aged
Postoperative Complications
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Factors
Sex Factors
Smoking
Survival Analysis
Treatment Outcome
English
OBJECTIVE AND METHODS
To characterize gender differences in lung cancer, we conducted a retrospective analysis including all patients undergoing surgery for non-small cell lung carcinoma in a single institution over a 20-year period.
RESULTS
Compared with men (n = 839), women (n = 198) were more likely to be asymptomatic (32% vs 20%, P =.006), nonsmokers (27% vs 2%, P <.001), or light smokers (31 pack-years vs 52 pack-years; P <.001). Squamous cell carcinoma predominated in men (65%), and adenocarcinoma predominated in women (54%). Preoperative bronchoscopy contributed more frequently to a histologic diagnosis in men (69% vs 49% in women, P <.001), and fewer pneumonectomies were performed in women (22% vs 32% in men, P =.01). After multivariate Cox regression analysis, women survived longer than men (hazard ratio, 0.72; 95% confidence interval, 0.56-0. 92; P =.009) independently of age, presence of symptoms, smoking habits, type of operation, histologic characteristics, and stage of disease. The protective effect linked to female sex was present in early-stage carcinoma (stage I and II) and absent in more advanced-stage carcinoma (stage III and IV).
CONCLUSIONS
This study emphasizes strong sex differences in presentation, management, and prognosis of patients with non-small cell lung cancer.
To characterize gender differences in lung cancer, we conducted a retrospective analysis including all patients undergoing surgery for non-small cell lung carcinoma in a single institution over a 20-year period.
RESULTS
Compared with men (n = 839), women (n = 198) were more likely to be asymptomatic (32% vs 20%, P =.006), nonsmokers (27% vs 2%, P <.001), or light smokers (31 pack-years vs 52 pack-years; P <.001). Squamous cell carcinoma predominated in men (65%), and adenocarcinoma predominated in women (54%). Preoperative bronchoscopy contributed more frequently to a histologic diagnosis in men (69% vs 49% in women, P <.001), and fewer pneumonectomies were performed in women (22% vs 32% in men, P =.01). After multivariate Cox regression analysis, women survived longer than men (hazard ratio, 0.72; 95% confidence interval, 0.56-0. 92; P =.009) independently of age, presence of symptoms, smoking habits, type of operation, histologic characteristics, and stage of disease. The protective effect linked to female sex was present in early-stage carcinoma (stage I and II) and absent in more advanced-stage carcinoma (stage III and IV).
CONCLUSIONS
This study emphasizes strong sex differences in presentation, management, and prognosis of patients with non-small cell lung cancer.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/s0022-5223(00)70213-3
- PMID 10612756
- Persistent URL
- https://sonar.ch/global/documents/127668
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