The Interplay between Adeno-Associated Virus and its Helper Viruses.
- Meier AF Institute of Virology, University of Zurich, CH-8057 Zurich, Switzerland.
- Fraefel C Institute of Virology, University of Zurich, CH-8057 Zurich, Switzerland.
- Seyffert M Institute of Virology, University of Zurich, CH-8057 Zurich, Switzerland.
- 2020-06-25
Published in:
- Viruses. - 2020
adeno-associated virus
adenovirus
helper virus
herpes simplex virus
viral coinfections
viral vectors
English
The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.3390/v12060662
- PMID 32575422
- Persistent URL
- https://sonar.ch/global/documents/128719
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