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Methylated cytosine and the brain: a new base for neuroscience.
Journal article

Methylated cytosine and the brain: a new base for neuroscience.

  • Tucker KL Friedrich Miescher Institute for Biomedical Research, 4058, Basel, Switzerland.
  • 2001-06-30
Published in:
  • Neuron. - 2001
Animals
Brain
Chromosomal Proteins, Non-Histone
Cytosine
DNA Methylation
DNA-Binding Proteins
Methyl-CpG-Binding Protein 2
Mice
Mice, Knockout
Repressor Proteins
English Methylation of genomic CpG residues is crucial for proper neuronal function. Rett syndrome, a common form of mental retardation, is associated with mutations in the gene encoding MeCP2, a methyl CpG binding protein linked to transcriptional repression. Gene knockouts of mouse Mecp2 have reproduced key aspects of the disease. A CNS-restricted knockout of Dnmt1, encoding the enzyme that maintains CpG methylation patterns, results in loss of mutant neurons and glia.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/129385
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