Journal article
Quantitative 99mTc-DPD SPECT/CT in patients with suspected ATTR cardiac amyloidosis: Feasibility and correlation with visual scores.
- Caobelli F Nuclear Medicine Department, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland. Federico.caobelli@usb.ch.
- Braun M Nuclear Medicine Department, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
- Haaf P Cardiology Department, University Hospital Basel, University of Basel, Basel, Switzerland.
- Wild D Nuclear Medicine Department, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
- Zellweger MJ Cardiology Department, University Hospital Basel, University of Basel, Basel, Switzerland.
- 2019-09-21
Published in:
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. - 2020
English
PURPOSE
While a visual interpretation of 99mTc-DPD scintigraphy by means of Perugini score can provide a reliable diagnosis of transthyretin-related (ATTR) cardiac amyloidosis (CA), a quantitative approach is expected to play a major role in risk stratification and therapy evaluation. The aim of our study was to test the feasibility of a quantitative assessment and to correlate various parameters to Perugini score.
METHODS
in this retrospective study, consecutive patients underwent a 99mTc-DPD whole-body bone scintigraphy and a SPECT/CT of the thorax. XSPECT-QUANT software was used to quantify the DPD uptake in the heart.
RESULTS
Thirteen patients were included. CA was confirmed in 8 and rejected in 5. Myocardial SUVmax and SUVpeak showed a fairly strong correlation with Perugini score (both ρ = .71, P = .006). Same held true for to-bone normalized values (both ρ = .75, P = .003). There was a great degree of overlap for quantitative values in patients with Perugini score 2 and 3.
CONCLUSION
Quantitative 99mTc-DPD SPECT/CT in suspected ATTR CA patients is feasible and allows for a more accurate assessment of myocardial uptake.
While a visual interpretation of 99mTc-DPD scintigraphy by means of Perugini score can provide a reliable diagnosis of transthyretin-related (ATTR) cardiac amyloidosis (CA), a quantitative approach is expected to play a major role in risk stratification and therapy evaluation. The aim of our study was to test the feasibility of a quantitative assessment and to correlate various parameters to Perugini score.
METHODS
in this retrospective study, consecutive patients underwent a 99mTc-DPD whole-body bone scintigraphy and a SPECT/CT of the thorax. XSPECT-QUANT software was used to quantify the DPD uptake in the heart.
RESULTS
Thirteen patients were included. CA was confirmed in 8 and rejected in 5. Myocardial SUVmax and SUVpeak showed a fairly strong correlation with Perugini score (both ρ = .71, P = .006). Same held true for to-bone normalized values (both ρ = .75, P = .003). There was a great degree of overlap for quantitative values in patients with Perugini score 2 and 3.
CONCLUSION
Quantitative 99mTc-DPD SPECT/CT in suspected ATTR CA patients is feasible and allows for a more accurate assessment of myocardial uptake.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1007/s12350-019-01893-8
- PMID 31538322
- Persistent URL
- https://sonar.ch/global/documents/130449
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