Journal article

Biphenotypic (hepatobiliary) primary liver carcinomas: the work in progress.

  • Brunt EM Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Paradis V Department of Pathology, Beaujon Hospital, 92118 Clichy, France.
  • Sempoux C Institute of Pathology, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland.
  • Theise ND Departments of Pathology & Medicine, Mount Sinai Beth Israel Medical Center, Icahn School of Medicine at Mount Sinai, New York, NY 10002, USA.
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  • 2018-09-08
Published in:
  • Hepatic oncology. - 2015
English Recent WHO classification for combined hepatocellular-cholangiocarcinoma and recognized stem cell subtypes has increased attention to such tumors; however, the resulting burst of reporting and research indicates that this classification, while provocative, is incomplete for description of the full array of primary liver carcinomas with biphenotypic (hepatobiliary) differentiation. We review the history of such lesions and consider the wider array of such tumors previously described. Mixed hepatobiliary phenotypes and immunophenotypes are found in individual tumors at the tissue level - with architectural and cytologic features supportive of both differentiation states - and at the cellular level, with individual cells that display cytology of one cell type, but immunophenotypically showing mixed expression. Pathobiologic and clinical questions to be answered by future research are suggested.
Language
  • English
Open access status
green
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https://sonar.ch/global/documents/13045
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