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Intracellular pattern recognition receptors in the host response.
Journal article

Intracellular pattern recognition receptors in the host response.

  • Meylan E Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.
  • Tschopp J
  • Karin M
  • 2006-07-11
Published in:
  • Nature. - 2006
Adaptor Proteins, Signal Transducing
Animals
Humans
Immunity, Innate
Inflammation
Intracellular Signaling Peptides and Proteins
RNA, Viral
English The innate immune system relies on its capacity to rapidly detect invading pathogenic microbes as foreign and eliminate them. Indeed, Toll-like receptors are a class of membrane receptors that sense extracellular microbes and trigger anti-pathogen signalling cascades. Recently, intracellular microbial sensors have also been identified, including NOD-like receptors and the helicase-domain-containing antiviral proteins RIG-I and MDA5. Some of these cytoplasmic molecules sense microbial, as well as non-microbial, danger signals, but the mechanisms of recognition used by these sensors remain poorly understood. Nonetheless, it is apparent that these proteins are likely to have critical roles in health and disease.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/130850
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