Synthesis of ether oligomers.

Renaudet O; Reymond JL

doi:10.1021/ol036300d

Back

Journal article

Synthesis of ether oligomers.

Renaudet O Department of Chemistry and Biochemistry, University of Bern, Switzerland.
Reymond JL

2004-01-30

Published in:

Organic letters. - 2004

English [structure: see text] Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.

Language