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Journal article

2,3-butanediol in experimental myocardial ischaemia in pigs.

  • 1991-05-01
Published in:
  • European heart journal. - 1991
Animals
Butylene Glycols
Coronary Disease
Coronary Vessels
Ischemia
Lactates
Lactic Acid
Myocardium
Swine
English To investigate the role of 2,3-butanediol in myocardial ischaemia we analysed this compound in pig's myocardium and blood. Ischaemia was induced by ligation of a coronary artery. In the first study we found significantly higher levels of 2,3-butanediol in the homogenate of ischaemic myocardium than in non-ischaemic myocardium. The lactate concentration was also significantly elevated. In the second study, where ischaemia was similarly induced, and where reperfusion was achieved by re-opening the ligated coronary artery after 20 min, 2,3-butanediol in peripheral blood was found to increase significantly. In the pigs in which the coronary artery was not re-opened, the 2,3-butanediol level in peripheral blood was unchanged. We conclude that in pigs' anaerobic myocardia accumulation of 2,3-butanediol occurs; if the myocardium is reperfused this metabolite also appears in the blood.
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  • English
Open access status
green
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https://sonar.ch/global/documents/131373
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