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Keratinocyte growth factor: effects on keratinocytes and mechanisms of action.
Journal article

Keratinocyte growth factor: effects on keratinocytes and mechanisms of action.

  • 2005-02-01
Published in:
  • European journal of cell biology. - 2004
Animals
Fibroblast Growth Factor 7
Fibroblast Growth Factors
Humans
Keratinocytes
Mitogens
Receptor, Fibroblast Growth Factor, Type 2
Receptors, Fibroblast Growth Factor
Signal Transduction
Wound Healing
English Keratinocyte growth factor (KGF) is a potent and specific mitogen for different types of epithelial cells, and it can protect these cells from various insults. Due to these properties, it is of particular importance for the repair of injured epithelial tissues, and it is currently therapeutically explored for the treatment of radiation- and chemotherapy-induced mucosal epithelial damage in cancer patients. In this review we summarize the current knowledge on the role of KGF in tissue repair and cytoprotection, and we report on its mechanisms of action in keratinocytes.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/132622
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