And the fat lady sings about phosphate and calcium.
- Wagner CA Institute of Physiology, University of Zurich, Switzerland, and NCCR Kidney.CH, Switzerland. Electronic address: Wagnerca@access.uzh.ch.
- Imenez Silva PH Institute of Physiology, University of Zurich, Switzerland, and NCCR Kidney.CH, Switzerland.
- Rubio-Aliaga I Institute of Physiology, University of Zurich, Switzerland, and NCCR Kidney.CH, Switzerland.
- 2017-01-15
Published in:
- Kidney international. - 2017
English
Adipose tissue has been long recognized as secreting various endocrine factors. Emerging evidence demonstrates that adipokines play a role in modulating systemic mineral homeostasis through endocrine loops involving interleukin-6, leptin, and now also adiponectin, which all interact with FGF23 and vitamin D and thereby change the renal control of calcium and phosphate metabolism. Understanding these regulatory loops may shed light on a complex interorgan crosstalk controlling mineral homeostasis and its dysregulation in diseases associated with obesity.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/j.kint.2016.11.009
- PMID 28087005
- Persistent URL
- https://sonar.ch/global/documents/134794
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