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Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types.

  • He L Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin 300052, China.
  • Vanlandewijck M Integrated Cardio Metabolic Centre, Department of Medicine Huddinge, Karolinska Institutet, Blickagången 6, SE-141 57 Huddinge, Sweden.
  • Mäe MA Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85 Uppsala, Sweden.
  • Andrae J Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85 Uppsala, Sweden.
  • Ando K Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85 Uppsala, Sweden.
  • Del Gaudio F Department of Cell and Molecular Biology, Karolinska Institutet, Von Eulers väg 3, SE-171 77 Stockholm, Sweden.
  • Nahar K Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85 Uppsala, Sweden.
  • Lebouvier T Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85 Uppsala, Sweden.
  • Laviña B Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85 Uppsala, Sweden.
  • Gouveia L Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85 Uppsala, Sweden.
  • Sun Y Department of Bioinformatics, Zhongyuan Union Genetic Technology Co., Ltd., No.45, the 9th East Road, Tianjin airport economic area, Tianjin 300304, China.
  • Raschperger E Integrated Cardio Metabolic Centre, Department of Medicine Huddinge, Karolinska Institutet, Blickagången 6, SE-141 57 Huddinge, Sweden.
  • Segerstolpe Å Integrated Cardio Metabolic Centre, Department of Medicine Huddinge, Karolinska Institutet, Blickagången 6, SE-141 57 Huddinge, Sweden.
  • Liu J Integrated Cardio Metabolic Centre, Department of Medicine Huddinge, Karolinska Institutet, Blickagången 6, SE-141 57 Huddinge, Sweden.
  • Gustafsson S Integrated Cardio Metabolic Centre, Department of Medicine Huddinge, Karolinska Institutet, Blickagången 6, SE-141 57 Huddinge, Sweden.
  • Räsänen M Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, FI-00014 Helsinki, Finland.
  • Zarb Y Division of Neurosurgery, Zürich University Hospital, Zürich University, Zürich, CH-8091, Switzerland.
  • Mochizuki N Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.
  • Keller A Division of Neurosurgery, Zürich University Hospital, Zürich University, Zürich, CH-8091, Switzerland.
  • Lendahl U Integrated Cardio Metabolic Centre, Department of Medicine Huddinge, Karolinska Institutet, Blickagången 6, SE-141 57 Huddinge, Sweden.
  • Betsholtz C Integrated Cardio Metabolic Centre, Department of Medicine Huddinge, Karolinska Institutet, Blickagången 6, SE-141 57 Huddinge, Sweden.
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  • 2018-08-22
Published in:
  • Scientific data. - 2018
Animals
Blood Vessels
Brain
Databases, Factual
Endothelial Cells
Lung
Mice
Myocytes, Smooth Muscle
Pericytes
Sequence Analysis, RNA
Single-Cell Analysis
Transcriptome
English Vascular diseases are major causes of death, yet our understanding of the cellular constituents of blood vessels, including how differences in their gene expression profiles create diversity in vascular structure and function, is limited. In this paper, we describe a single-cell RNA sequencing (scRNA-seq) dataset that defines vascular and vessel-associated cell types and subtypes in mouse brain and lung. The dataset contains 3,436 single cell transcriptomes from mouse brain, which formed 15 distinct clusters corresponding to cell (sub)types, and another 1,504 single cell transcriptomes from mouse lung, which formed 17 cell clusters. In order to allow user-friendly access to our data, we constructed a searchable database (http://betsholtzlab.org/VascularSingleCells/database.html). Our dataset constitutes a comprehensive molecular atlas of vascular and vessel-associated cell types in the mouse brain and lung, and as such provides a strong foundation for future studies of vascular development and diseases.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/135122
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