Nuclear export of mRNA.
- Zenklusen D Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, 44, rue du Bugnon, 1011, Lausanne, Switzerland.
- Stutz F
- 2001-06-20
Published in:
- FEBS letters. - 2001
Active Transport, Cell Nucleus
Animals
Cell Nucleus
Heterogeneous-Nuclear Ribonucleoproteins
Humans
Models, Biological
Nuclear Pore
Nuclear Proteins
Nucleocytoplasmic Transport Proteins
Protein Binding
RNA, Messenger
RNA-Binding Proteins
Ribonucleoproteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
English
Export of mRNA through nuclear pore complexes (NPC) is preceded by multiple and well coordinated processing steps, resulting in the formation of an export competent ribonucleoprotein complex (mRNP). Numerous factors involved in the translocation of the mRNP through the NPC and its release into the cytoplasm have been isolated mainly through genetic approaches in yeast, and putative functional homologues have been identified in metazoan systems. Understanding the mechanism of mRNA export relies, in part, on the functional characterization of these factors and the establishment of a complete network of molecular interactions. Here we summarize recent progress in the characterization of yeast and mammalian components implicated in the export of an mRNA from the nucleus to the cytoplasm.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1016/s0014-5793(01)02482-6
- PMID 11412847
- Persistent URL
- https://sonar.ch/global/documents/136276
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