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Lymphatic outflow of cerebrospinal fluid is reduced in glioma.

  • Ma Q Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.
  • Schlegel F Institute of Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
  • Bachmann SB Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.
  • Schneider H Laboratory of Molecular Neuro-Oncology, Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
  • Decker Y Department of Neurology, University of the Saarland, Homburg, Germany.
  • Rudin M Institute of Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
  • Weller M Laboratory of Molecular Neuro-Oncology, Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
  • Proulx ST Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland. steven.proulx@tki.unibe.ch.
  • Detmar M Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland. michael.detmar@pharma.ethz.ch.
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  • 2019-10-17
Published in:
  • Scientific reports. - 2019
Animals
Brain Neoplasms
Cell Line, Tumor
Cerebrospinal Fluid
Cisterna Magna
Disease Models, Animal
Female
Glioblastoma
Glymphatic System
Humans
Hydrodynamics
Intracranial Hypertension
Magnetic Resonance Imaging
Mice
Spectroscopy, Near-Infrared
English Glioblastoma is a malignant brain tumor with mean overall survival of less than 15 months. Blood vessel leakage and peritumoral edema lead to increased intracranial pressure and augment neurological deficits which profoundly decrease the quality of life of glioblastoma patients. It is unknown how the dynamics of cerebrospinal fluid (CSF) turnover are affected during this process. By monitoring the transport of CSF tracers to the systemic blood circulation after infusion into the cisterna magna, we demonstrate that the outflow of CSF is dramatically reduced in glioma-bearing mice. Using a combination of magnetic resonance imaging (MRI) and near-infrared (NIR) imaging, we found that the circulation of CSF tracers was hindered after cisterna magna injection with reduced signals along the exiting cranial nerves and downstream lymph nodes, which represent the major CSF outflow route in mice. Due to blockage of the normal routes of CSF bulk flow within and from the cranial cavity, CSF tracers were redirected into the spinal space. In some mice, impaired CSF clearance from the cranium was compensated by a lymphatic outflow from the sacral spine.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/136462
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