Journal article
Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial.
- Berger MM Soins Intensifs de Chirurgie, CHUV, Lausanne, Switzerland. Mette.Berger@chuv.hospvd.ch
- Reymond MJ
- Shenkin A
- Rey F
- Wardle C
- Cayeux C
- Schindler C
- Chioléro RL
- 2001-03-31
Published in:
- Intensive care medicine. - 2001
Adult
Analysis of Variance
Antioxidants
Drug Therapy, Combination
Euthyroid Sick Syndromes
Humans
Prospective Studies
Selenium
Thyroxine
Triiodothyronine, Reverse
Vitamin E
Wounds and Injuries
Zinc
English
OBJECTIVE
To investigate whether early selenium (Se) supplementation can modify the post-traumatic alterations of thyroid hormone metabolism, since the first week after trauma is characterised by low plasma Se and negative Se balances.
DESIGN
Prospective, placebo-controlled randomised supplementation trial.
SETTING
Surgical ICU in a tertiary university hospital.
PATIENTS
Thirty-one critically ill trauma patients aged 42 +/- 16 years (mean +/- SD), with severe multiple injury (Injury Severity Score 30 +/- 7).
INTERVENTION
Supplementation during the first 5 days after injury with either Se or placebo. The selenium group was further randomised to receive daily 500 microg Se, with or without 150 mg alpha-tocopherol (AT) and 13 mg zinc supplements. The placebo group received the vehicle. Circulating Se, AT, zinc, and thyroid hormones were determined on D0 (= day 0, admission), D1, D2, D5, D10, and D20.
RESULTS
Plasma Se, low on D0, normalised from D1 in the selenium group; total T4 and T3 increased more and faster after D2 (P = 0.04 and 0.08), reverse T3 rising less between D0 and D2 (P = 0.05).
CONCLUSIONS
Selenium supplements increased the circulating Se levels. Supplementation was associated with modest changes in thyroid hormones, with an earlier normalisation of T4 and reverse T3 plasma levels. The addition of AT and zinc did not produce any additional change.
To investigate whether early selenium (Se) supplementation can modify the post-traumatic alterations of thyroid hormone metabolism, since the first week after trauma is characterised by low plasma Se and negative Se balances.
DESIGN
Prospective, placebo-controlled randomised supplementation trial.
SETTING
Surgical ICU in a tertiary university hospital.
PATIENTS
Thirty-one critically ill trauma patients aged 42 +/- 16 years (mean +/- SD), with severe multiple injury (Injury Severity Score 30 +/- 7).
INTERVENTION
Supplementation during the first 5 days after injury with either Se or placebo. The selenium group was further randomised to receive daily 500 microg Se, with or without 150 mg alpha-tocopherol (AT) and 13 mg zinc supplements. The placebo group received the vehicle. Circulating Se, AT, zinc, and thyroid hormones were determined on D0 (= day 0, admission), D1, D2, D5, D10, and D20.
RESULTS
Plasma Se, low on D0, normalised from D1 in the selenium group; total T4 and T3 increased more and faster after D2 (P = 0.04 and 0.08), reverse T3 rising less between D0 and D2 (P = 0.05).
CONCLUSIONS
Selenium supplements increased the circulating Se levels. Supplementation was associated with modest changes in thyroid hormones, with an earlier normalisation of T4 and reverse T3 plasma levels. The addition of AT and zinc did not produce any additional change.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1007/s001340000757
- PMID 11280679
- Persistent URL
- https://sonar.ch/global/documents/137260
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