Journal article
The pathogenesis of optic disc splinter haemorrhages: a new hypothesis.
- Grieshaber MC University Eye Clinic, University Hospital of Basel, Basel, Switzerland.
- Terhorst T
- Flammer J
- 2006-02-01
Published in:
- Acta ophthalmologica Scandinavica. - 2006
Blood Flow Velocity
Blood Pressure
Blood-Retinal Barrier
Cold Temperature
Endothelin-1
Female
Humans
Intraocular Pressure
Middle Aged
Nails
Optic Disk
Peripheral Vascular Diseases
Philosophy
Regional Blood Flow
Retinal Hemorrhage
Visual Fields
English
PURPOSE
To describe a hypothesized relationship between optic disc haemorrhages (ODHs) and primary vascular dysregulation (PVD).
METHODS
Observational case report of a patient with classical PVD and five bilateral recurrent ODHs
RESULTS
The ODHs were superotemporal in the right eye and inferotemporal in the left; the eyes were otherwise normal. Intraocular pressure (IOP) never exceeded 17 mmHg. Visual fields were normal. Increased blood flow resistivity, a reduced blood flow of the extraocular vessels, a low systemic blood pressure, a cold-induced flow stop of the nailfold capillaries, and elevated endothelin-1 plasma levels were found, all confirming the diagnosis of vascular dysregulation.
CONCLUSIONS
Optic disc haemorrhages may be due to a disturbed blood-retina barrier rather than to a mechanical rupture of the vessel. This barrier dysfunction may occur in the context of PVD.
To describe a hypothesized relationship between optic disc haemorrhages (ODHs) and primary vascular dysregulation (PVD).
METHODS
Observational case report of a patient with classical PVD and five bilateral recurrent ODHs
RESULTS
The ODHs were superotemporal in the right eye and inferotemporal in the left; the eyes were otherwise normal. Intraocular pressure (IOP) never exceeded 17 mmHg. Visual fields were normal. Increased blood flow resistivity, a reduced blood flow of the extraocular vessels, a low systemic blood pressure, a cold-induced flow stop of the nailfold capillaries, and elevated endothelin-1 plasma levels were found, all confirming the diagnosis of vascular dysregulation.
CONCLUSIONS
Optic disc haemorrhages may be due to a disturbed blood-retina barrier rather than to a mechanical rupture of the vessel. This barrier dysfunction may occur in the context of PVD.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1111/j.1600-0420.2005.00590.x
- PMID 16445441
- Persistent URL
- https://sonar.ch/global/documents/137559
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