Journal article
Multimodal Outcome at 7 Years of Age after Neonatal Arterial Ischemic Stroke.
- Chabrier S Centre Hospitalier Universitaire (CHU) Saint-Étienne, French Center for Pediatric Stroke/Pediatric Physical and Rehabilitation Medicine Department and Institut national de la santé et de la recherche médicale Centre d'investigation Clinique (INSERM CIC) 1408, Saint-Étienne, France; INSERM and University of Lyon, Dysfonction vasculaire et hémostase (DVH) Team-Unité mixte de recherche (UMR) 1090 Sainbiose, Saint-Étienne, France. Electronic address: stephane.chabrier@chu-st-etienne.fr.
- Peyric E Centre Hospitalier Universitaire (CHU) Saint-Étienne, French Center for Pediatric Stroke/Pediatric Physical and Rehabilitation Medicine Department and Institut national de la santé et de la recherche médicale Centre d'investigation Clinique (INSERM CIC) 1408, Saint-Étienne, France.
- Drutel L Centre Hospitalier Universitaire (CHU) Saint-Étienne, French Center for Pediatric Stroke/Pediatric Physical and Rehabilitation Medicine Department and Institut national de la santé et de la recherche médicale Centre d'investigation Clinique (INSERM CIC) 1408, Saint-Étienne, France.
- Deron J Centre Hospitalier Universitaire (CHU) Saint-Étienne, French Center for Pediatric Stroke/Pediatric Physical and Rehabilitation Medicine Department and Institut national de la santé et de la recherche médicale Centre d'investigation Clinique (INSERM CIC) 1408, Saint-Étienne, France.
- Kossorotoff M Assistance publique-Hôpitaux de Paris (AP-HP), French Center for Pediatric Stroke/Pediatric Neurology Department, University Hospital Necker-Enfants Malades, Paris, France; INSERM and University of Paris 5, Thérapeutiques innovantes en hémostase-UMRS1140, Paris, France.
- Dinomais M Physical and Rehabilitation Medicine Department, L'Université Nantes Angers le Mans (LUNAM) CHU Angers, Angers, France; Laboratoire Angevin de Recherche en Ingénierie des systèmes (LARIS)-EA7315, LUNAM Université Angers, Angers, France.
- Lazaro L Pediatrics Department, Centre hospitalier (CH) Côte-Basque, Bayonne, France.
- Lefranc J Pediatrics and Medical Genetics Deparment, CHU Brest, Brest, France.
- Thébault G INSERM and University of Lyon, Dysfonction vasculaire et hémostase (DVH) Team-Unité mixte de recherche (UMR) 1090 Sainbiose, Saint-Étienne, France; Dynamique des capacités humaines et des conduites de santé -Laboratory Epsylon EA4556, Université Montpellier 3, Montpellier, France.
- Dray G Mines Alès, Laboratoire de génie informatique et d'ingénierie de production (LG2IP), Nîmes, France.
- Fluss J Pediatric Neurology, Pediatric Subspecialties Service, Children's Hospital, Geneva University Hospital, Geneva, Switzerland.
- Renaud C Centre Hospitalier Universitaire (CHU) Saint-Étienne, French Center for Pediatric Stroke/Pediatric Physical and Rehabilitation Medicine Department and Institut national de la santé et de la recherche médicale Centre d'investigation Clinique (INSERM CIC) 1408, Saint-Étienne, France; INSERM and University of Lyon, Dysfonction vasculaire et hémostase (DVH) Team-Unité mixte de recherche (UMR) 1090 Sainbiose, Saint-Étienne, France.
- Nguyen The Tich S Laboratoire Angevin de Recherche en Ingénierie des systèmes (LARIS)-EA7315, LUNAM Université Angers, Angers, France; Neuropediatrics Department, LUNAM CHU Angers, Angers, France.
- 2016-03-13
Published in:
- The Journal of pediatrics. - 2016
Child
Child, Preschool
Cohort Studies
Developmental Disabilities
Epilepsy
Female
Humans
Infant
Infant, Newborn
Male
Stroke
English
OBJECTIVES
To evaluate the epileptic, academic, and developmental status at age 7 years in a large population of term-born children who sustained neonatal arterial ischemic stroke (NAIS), and to assess the co-occurrence of these outcomes.
STUDY DESIGN
A cohort study including 100 term newborns with NAIS was designed. Two infants died during the neonatal period, 13 families were lost to follow-up, and 5 families declined to participate in this evaluation. Thus, 80 families completed the 7-year clinical assessment. Epileptic status, schooling, motor abilities, global intellectual functioning, spoken language, and parental opinions were recorded. Principal component analysis was applied.
RESULTS
Rates of impaired language, cerebral palsy, low academic skills, active epilepsy, and global intellectual deficiency were 49%, 32%, 28%, 11%, and 8%, respectively. All were highly correlated. Eventually, 59% of children were affected by at least 1 of the aforementioned conditions. In 30% of cases, the viewpoints of health practitioners and parents did not match.
CONCLUSION
The prevalence of severe disabilities at 7 years after NAIS is low, but most children exhibit some impairment in developmental profile.
TRIAL REGISTRATION
ClinicalTrials.gov (NCT02511249), Programme Hospitalier de Recherche Clinique Régional (0308052), Programme Hospitalier de Recherche Clinique Interrégional (1008026), and EudraCT (2010-A00329-30).
To evaluate the epileptic, academic, and developmental status at age 7 years in a large population of term-born children who sustained neonatal arterial ischemic stroke (NAIS), and to assess the co-occurrence of these outcomes.
STUDY DESIGN
A cohort study including 100 term newborns with NAIS was designed. Two infants died during the neonatal period, 13 families were lost to follow-up, and 5 families declined to participate in this evaluation. Thus, 80 families completed the 7-year clinical assessment. Epileptic status, schooling, motor abilities, global intellectual functioning, spoken language, and parental opinions were recorded. Principal component analysis was applied.
RESULTS
Rates of impaired language, cerebral palsy, low academic skills, active epilepsy, and global intellectual deficiency were 49%, 32%, 28%, 11%, and 8%, respectively. All were highly correlated. Eventually, 59% of children were affected by at least 1 of the aforementioned conditions. In 30% of cases, the viewpoints of health practitioners and parents did not match.
CONCLUSION
The prevalence of severe disabilities at 7 years after NAIS is low, but most children exhibit some impairment in developmental profile.
TRIAL REGISTRATION
ClinicalTrials.gov (NCT02511249), Programme Hospitalier de Recherche Clinique Régional (0308052), Programme Hospitalier de Recherche Clinique Interrégional (1008026), and EudraCT (2010-A00329-30).
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.jpeds.2016.01.069
- PMID 26968833
- Persistent URL
- https://sonar.ch/global/documents/137682
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