Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.

• Lotta LA MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
• Gulati P Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
• Day FR MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
• Payne F Wellcome Trust Sanger Institute, Hinxton, UK.
• Ongen H Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
• van de Bunt M Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
• Gaulton KJ Department of Pediatrics, University of California at San Diego, La Jolla, California, USA.
• Eicher JD Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
• Sharp SJ MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
• Luan J MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
• De Lucia Rolfe E MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
• Stewart ID MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
• Wheeler E Wellcome Trust Sanger Institute, Hinxton, UK.
• Willems SM MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
• Adams C Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
• Yaghootkar H Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK.
• Forouhi NG Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
• Khaw KT Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
• Johnson AD Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK.
• Semple RK MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
• Frayling T Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
• Perry JR Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
• Dermitzakis E Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
• McCarthy MI MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
• Barroso I Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
• Wareham NJ MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
• Savage DB Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
• Langenberg C MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
• O'Rahilly S
• Scott RA

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Adipose Tissue

Animals

Blood Glucose

Body Mass Index

Cardiovascular Diseases

Case-Control Studies

Disease Models, Animal

Female

Genome-Wide Association Study

Genomics

Humans

Insulin Resistance

Male

Metabolic Diseases

Mice

Obesity

Phenotype