Journal article
CatSper: The complex main gate of calcium entry in mammalian spermatozoa.
- Rahban R Swiss Centre for Applied Human Toxicology (SCAHT), Switzerland; Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, 1206, Geneva, Switzerland. Electronic address: Rita.Rahban@unige.ch.
- Nef S Swiss Centre for Applied Human Toxicology (SCAHT), Switzerland; Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, 1206, Geneva, Switzerland. Electronic address: serge.nef@unige.ch.
- 2020-07-27
Published in:
- Molecular and cellular endocrinology. - 2020
English
Calcium ions (Ca2+) are involved in nearly every aspect of cellular life. They are one of the most abundant elements in mammals and play a vital role in physiological and biochemical processes acting mainly as intracellular messengers. In spermatozoa, several key functions are regulated by cytoplasmic Ca2+ concentration such as sperm capacitation, chemotaxis, hyperactive motility, and acrosome reaction. The sperm-specific ion channel CatSper is the principal calcium channel in sperm mediating the calcium influx into the sperm flagellum and acting as an essential modulator of downstream mechanisms involved in fertilization. This review aims to provide insights into the structure, localization, and function of the mammalian CatSper channel, primarily human and mice. The activation of CatSper by progesterone and prostaglandins, as well as the ligand-independent regulation of the channel by a change in the membrane voltage and intracellular pH are going to be addressed. Finally, major questions, challenges, and perspectives are discussed.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1016/j.mce.2020.110951
- PMID 32712386
- Persistent URL
- https://sonar.ch/global/documents/138156
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