Import of proteins into mitochondria.

Eilers M; Verner K; Hwang S; Schatz G

doi:10.1098/rstb.1988.0036

Back

Journal article

Import of proteins into mitochondria.

Eilers M Biocentre, University of Basle, Switzerland.
Verner K
Hwang S
Schatz G

1988-05-31

Published in:

Philosophical transactions of the Royal Society of London. Series B, Biological sciences. - 1988

Protein Processing, Post-Translational

Tetrahydrofolate Dehydrogenase

English A mounting body of evidence suggests that cytoplasmically synthesized proteins destined to be imported into the mitochondrial interior must at least partly unfold to penetrate across the mitochondrial membranes. During post-translational import, this unfolding process appears to be a major rate-limiting step. It can be blocked by ligands that stabilize the protein's native conformation and appears to be accompanied by the cleavage of ATP outside the mitochondrial inner membrane.

Language