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Journal article

Role of the sympathetic nervous system during the development of obesity-induced hypertension in rabbits.

  • 2000-05-29
Published in:
  • American journal of hypertension. - 2000
Adrenergic alpha-Antagonists
Adrenergic beta-Antagonists
Animals
Blood Pressure
Blood Pressure Determination
Dietary Fats
Glomerular Filtration Rate
Heart Rate
Hypertension
Injections, Intravenous
Kidney
Male
Obesity
Phenylephrine
Prazosin
Propranolol
Rabbits
Sodium
Sympathetic Nervous System
Sympathomimetics
Telemetry
English We have previously reported that weight gain induced by high-fat diet (HFD) leads to an increase in mean arterial pressure (MAP, +14%) and heart rate (HR, +31%) in the adult rabbit. In the present study, we tested the hypothesis that an increased activity of the sympathetic nervous system may contribute to the development of obesity-induced hypertension. A combination of alpha- and beta-adrenergic blockers (terazosin + propranolol) was chronically administered to rabbits housed in metabolic cages for continuous monitoring of arterial pressure by telemetry, 24 h a day. After 2 weeks of adrenergic blockade under control diet, animals were switched to HFD for the next 6 weeks. HFD induced a progressive increase in body weight, but no increase in mean arterial pressure (+0.2+/-2.5%) and a slight increase in heart rate (+14+/-3%). Time-control animals fed normal diet showed no changes in MAP or HR with long-term alpha- and beta-adrenergic blockade. Our results indicate that the activation of the sympathetic nervous system may play an important role in the pathogenesis of obesity-induced hypertension.
Language
  • English
Open access status
green
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https://sonar.ch/global/documents/138722
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