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Cellular Basis of Bitter-Driven Aversive Behaviors in Drosophila Larva.

  • Choi J Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Yu S Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Choi MS Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Jang S Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Han IJ School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Maier GL Department of Biology, Institute of Zoology, University of Fribourg, Fribourg CH-1700, Switzerland.
  • Sprecher SG Department of Biology, Institute of Zoology, University of Fribourg, Fribourg CH-1700, Switzerland simon.sprecher@gmail.com jykwon@skku.edu.
  • Kwon JY Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea simon.sprecher@gmail.com jykwon@skku.edu.
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  • 2020-03-30
Published in:
  • eNeuro. - 2020
Drosophila
neural circuit
taste
English Feeding, a critical behavior for survival, consists of a complex series of behavioral steps. In Drosophila larvae, the initial steps of feeding are food choice, during which the quality of a potential food source is judged, and ingestion, during which the selected food source is ingested into the digestive tract. It remains unclear whether these steps employ different mechanisms of neural perception. Here, we provide insight into the two initial steps of feeding in Drosophila larva. We find that substrate choice and ingestion are determined by independent circuits at the cellular level. First, we took 22 candidate bitter compounds and examined their influence on choice preference and ingestion behavior. Interestingly, certain bitter tastants caused different responses in choice and ingestion, suggesting distinct mechanisms of perception. We further provide evidence that certain gustatory receptor neurons (GRNs) in the external terminal organ (TO) are involved in determining choice preference, and a pair of larval pharyngeal GRNs is involved in mediating both avoidance and suppression of ingestion. Our results show that feeding behavior is coordinated by a multistep regulatory process employing relatively independent neural elements. These findings are consistent with a model in which distinct sensory pathways act as modulatory circuits controlling distinct subprograms during feeding.
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  • English
Open access status
gold
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https://sonar.ch/global/documents/138845
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