Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis.
- Wettstein M Physiotherapy Institute, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
- Radlinger L Bern University of Applied Sciences, Health, Bern, Switzerland.
- Riedel T Paediatric and Neonatal Intensive Care Medicine, Department of Paediatrics, Inselspital, Bern University Children's Hospital and University of Bern, Bern, Switzerland.
- 2014-09-16
Published in:
- PloS one. - 2014
Adult
Continuous Positive Airway Pressure
Cystic Fibrosis
Female
Humans
Male
Middle Aged
Positive-Pressure Respiration
Posture
Pulmonary Ventilation
Tidal Volume
English
BACKGROUND AND OBJECTIVES
We investigated the effect of different breathing aids on ventilation distribution in healthy adults and subjects with cystic fibrosis (CF).
METHODS
In 11 healthy adults and 9 adults with CF electrical impedance tomography measurements were performed during spontaneous breathing, continuous positive airway pressure (CPAP) and positive expiratory pressure (PEP) therapy randomly applied in upright and lateral position. Spatial and temporal ventilation distribution was assessed.
RESULTS
The proportion of ventilation directed to the dependent lung significantly increased in lateral position compared to upright in healthy and CF. This effect was enhanced with CPAP but neutralised with PEP, whereas the effect of PEP was larger in the healthy group. Temporal ventilation distribution showed exactly the opposite with homogenisation during CPAP and increased inhomogeneity with PEP.
CONCLUSIONS
PEP shows distinct differences to CPAP with respect to its impact on ventilation distribution in healthy adults and CF subjects EIT might be used to individualise respiratory physiotherapy.
We investigated the effect of different breathing aids on ventilation distribution in healthy adults and subjects with cystic fibrosis (CF).
METHODS
In 11 healthy adults and 9 adults with CF electrical impedance tomography measurements were performed during spontaneous breathing, continuous positive airway pressure (CPAP) and positive expiratory pressure (PEP) therapy randomly applied in upright and lateral position. Spatial and temporal ventilation distribution was assessed.
RESULTS
The proportion of ventilation directed to the dependent lung significantly increased in lateral position compared to upright in healthy and CF. This effect was enhanced with CPAP but neutralised with PEP, whereas the effect of PEP was larger in the healthy group. Temporal ventilation distribution showed exactly the opposite with homogenisation during CPAP and increased inhomogeneity with PEP.
CONCLUSIONS
PEP shows distinct differences to CPAP with respect to its impact on ventilation distribution in healthy adults and CF subjects EIT might be used to individualise respiratory physiotherapy.
- Language
-
- English
- Open access status
- gold
- Identifiers
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- DOI 10.1371/journal.pone.0106591
- PMID 25222606
- Persistent URL
- https://sonar.ch/global/documents/138922
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