Journal article
Morphometric MRI Analysis: Improved Detection of Focal Cortical Dysplasia Using the MP2RAGE Sequence.
- Demerath T From the Departments of Neuroradiology (T.D., L.R., R.S., C.K., H.U.).
- Rubensdörfer L From the Departments of Neuroradiology (T.D., L.R., R.S., C.K., H.U.).
- Schwarzwald R From the Departments of Neuroradiology (T.D., L.R., R.S., C.K., H.U.).
- Schulze-Bonhage A Epileptology (A.S.-B., D.-M.A.), Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.
- Altenmüller DM Epileptology (A.S.-B., D.-M.A.), Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.
- Kaller C From the Departments of Neuroradiology (T.D., L.R., R.S., C.K., H.U.).
- Kober T Advanced Clinical Imaging Technology (T.K.), Siemens Healthcare AG, Lausanne, Switzerland.
- Huppertz HJ Swiss Epilepsy Clinic (H.-J.H.), Klinik Lengg AG, Zurich, Switzerland.
- Urbach H From the Departments of Neuroradiology (T.D., L.R., R.S., C.K., H.U.) horst.urbach@uniklinik-freiburg.de.
- 2020-06-06
Published in:
- AJNR. American journal of neuroradiology. - 2020
Adolescent
Adult
Child
Female
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Male
Malformations of Cortical Development
Middle Aged
Neuroimaging
English
BACKGROUND AND PURPOSE
Focal cortical dysplasias are the most common resected epileptogenic lesions in children and the third most common lesion in adults, but they are often subtle and frequently overlooked on MR imaging. The purpose of this study was to evaluate whether MP2RAGE-based morphometric MR imaging analysis is superior to MPRAGE-based analysis in the detection of focal cortical dysplasia.
MATERIALS AND METHODS
MPRAGE and MP2RAGE datasets were acquired in a consecutive series of 640 patients with epilepsy. Datasets were postprocessed using the Morphometric Analysis Program to generate morphometric z score maps such as junction, extension, and thickness images based on both MPRAGE and MP2RAGE images. Focal cortical dysplasia lesions were manually segmented in the junction images, and volumes and mean z scores of the lesions were measured.
RESULTS
Of 21 focal cortical dysplasias discovered, all were clearly visible on MP2RAGE junction images, whereas 2 were not visible on MPRAGE junction images. In all except 4 patients, the volume of the focal cortical dysplasia was larger and mean lesion z scores were higher on MP2RAGE junction images compared with the MPRAGE-based images (P = .005, P = .013).
CONCLUSIONS
In this study, MP2RAGE-based morphometric analysis created clearer output maps with larger lesion volumes and higher z scores than the MPRAGE-based analysis. This new approach may improve the detection of subtle, otherwise overlooked focal cortical dysplasia.
Focal cortical dysplasias are the most common resected epileptogenic lesions in children and the third most common lesion in adults, but they are often subtle and frequently overlooked on MR imaging. The purpose of this study was to evaluate whether MP2RAGE-based morphometric MR imaging analysis is superior to MPRAGE-based analysis in the detection of focal cortical dysplasia.
MATERIALS AND METHODS
MPRAGE and MP2RAGE datasets were acquired in a consecutive series of 640 patients with epilepsy. Datasets were postprocessed using the Morphometric Analysis Program to generate morphometric z score maps such as junction, extension, and thickness images based on both MPRAGE and MP2RAGE images. Focal cortical dysplasia lesions were manually segmented in the junction images, and volumes and mean z scores of the lesions were measured.
RESULTS
Of 21 focal cortical dysplasias discovered, all were clearly visible on MP2RAGE junction images, whereas 2 were not visible on MPRAGE junction images. In all except 4 patients, the volume of the focal cortical dysplasia was larger and mean lesion z scores were higher on MP2RAGE junction images compared with the MPRAGE-based images (P = .005, P = .013).
CONCLUSIONS
In this study, MP2RAGE-based morphometric analysis created clearer output maps with larger lesion volumes and higher z scores than the MPRAGE-based analysis. This new approach may improve the detection of subtle, otherwise overlooked focal cortical dysplasia.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.3174/ajnr.A6579
- PMID 32499249
- Persistent URL
- https://sonar.ch/global/documents/138961
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