Journal article
Assembly of macromolecular pores by immune defense systems.
- Peitsch MC University of Lausanne, Epalinges, Switzerland.
- Tschopp J
- 1991-08-01
Published in:
- Current opinion in cell biology. - 1991
Animals
Antigens, CD
Blood Proteins
CD59 Antigens
Carrier Proteins
Cell Membrane Permeability
Complement Membrane Attack Complex
Cytotoxicity, Immunologic
Erythrocyte Membrane
Humans
Membrane Glycoproteins
Membrane Proteins
Perforin
Pore Forming Cytotoxic Proteins
Structure-Activity Relationship
T-Lymphocytes, Cytotoxic
Trypanosoma cruzi
English
Immune defence systems (complement, cytolytic lymphocytes) make use of transmembrane pores assembled from up to 20 soluble monomers in a highly regulated process to induce cell death. Inhibitors of pore formation have been found which protect blood, endothelial and epithelial cells from the destructive effect of complement lesions. Recently, a pore-forming protein showing immunological crossreactivity to complement C9 has been found in the protozoan parasite Trypanosoma cruzi, thereby extending this protein family and generalizing its means of generating non-selective membrane permeability.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/0955-0674(91)90045-z
- PMID 1722985
- Persistent URL
- https://sonar.ch/global/documents/138995
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