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Monoclonal anti-endotoxin antibodies for the treatment of gram-negative bacteremia and septic shock.
Journal article

Monoclonal anti-endotoxin antibodies for the treatment of gram-negative bacteremia and septic shock.

  • Baumgartner JD Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Switzerland.
  • 1990-10-01
Published in:
  • European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. - 1990
Antibodies, Bacterial
Antibodies, Monoclonal
Bacterial Infections
Gram-Negative Bacteria
Humans
Lipopolysaccharides
Sepsis
Shock, Septic
English The role of anti-endotoxin antibodies in the management of gram-negative bacteremia and the experimental and clinical studies on the cross-protection afforded by core LPS antibodies are reviewed. These studies did not achieve clarification of the epitope(s) and effector mechanism(s) involved in protection. Recently, two anti-lipid A IgM monoclonal antibodies, designated E5 and HA-1A, have been investigated in patients with gram-negative bacterial infections and clinical manifestations of septicemia. E5 reduced the mortality of patients if they were not in shock, whether they were bacteremic or not. A confirmatory study has been initiated. In contrast to E5, HA-1A protected patients whether they were in shock or not, but only when they were bacteremic at randomization. Although these studies suggest beneficial effects, the type of patients who may benefit from this expensive therapy should be further defined. Further investigations are needed to clarify the mechanisms of protection of these antibodies.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/139007
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