Back
Endoscopic subureteral collagen injection for the treatment of vesicoureteral reflux in infants and children.
Journal article

Endoscopic subureteral collagen injection for the treatment of vesicoureteral reflux in infants and children.

  • 1995-08-01
Published in:
  • The Journal of urology. - 1995
Adolescent
Child
Child, Preschool
Collagen
Cross-Linking Reagents
Cystoscopy
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Injections
Male
Recurrence
Time Factors
Vesico-Ureteral Reflux
English Between June 1988 and September 1994, 100 girls and 32 boys 2 months to 15.5 years old (average 4.9 years) with 204 refluxing ureteral units were treated by endoscopic subureteral collagen injection. The collagen injected was of bovine origin and cross-linked with glutaraldehyde (Zyplast*). Followup ranged from 3 to 75 months (mean 33). Reflux was absent in 62.7% of cases 3 months after 1 endoscopic subureteral injection. Improvement to reflux grades I and II, generally not requiring further treatment, occurred in a further 15.2% of cases. A total of 66 ureters was injected twice. The overall cure rate after 1 or 2 injections was 79.4% 3 months after injection. There was no correlation between the risk of recurrent reflux and initial degree of reflux. Late recurrence of reflux following a reflux-free period occurred in 11.3% of the 204 units during the observation period, which varied from 3 months to 6 1/4 years. Reflux was absent after 1 or 2 injections, including late recurrence, in 70.6% of cases and in an additional 13.2% recurrent reflux was grade I or II, not necessitating any further treatment. Considering these results, subureteral collagen injection remains an adequate method of treatment for vesicoureteral reflux in children.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/139054
Statistics
Document views: 8 File downloads: