Journal article
Carbaxylosides of 4-ethyl-2-oxo-2H-benzopyran-7-yl as non-hydrolyzable, orally active venous antithrombotic agents.
- Jeanneret V Institut de chimie organique de l'Université de Lausanne, BCH, Lausanne-Dorigny, Switzerland.
- Vogel P
- Renaut P
- Millet J
- Theveniaux J
- Barberousse V
- 1999-01-05
Published in:
- Bioorganic & medicinal chemistry letters. - 1998
English
A (-)-conduritol F derivative was condensed with 4-ethyl-7-hydroxy-2H-1-benzopyran-2-one and converted into (+)-4-ethyl-7-[(1'R,2'S,3'S,4'R)-2',3',4'- trihydroxycyclohexyloxy]-2H-1-benzopyran-2-one ((+)-2). Enantiomer (-)-2 was obtained from a (+)-conduritol F derivative. The carbaxyloside (-)-2 with the L-xylose configuration was more active than (+)-2 in the Wessler's model.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/s0960-894x(98)00283-2
- PMID 9873415
- Persistent URL
- https://sonar.ch/global/documents/139069
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