Volume expansion enhances plasma endothelin-1.
- Abdel-Sayed S Division of Hypertension and Vascular Medicine, University Hospital, Lausanne, Switzerland.
- Brunner HR
- Nussberger J
- 2003-12-04
Published in:
- American journal of hypertension. - 2003
Animals
Blood Pressure
Endothelin-1
Fluid Therapy
Heart Rate
Infusions, Intravenous
Male
Models, Animal
Rats
Rats, Inbred SHR
Rats, Wistar
Sodium Chloride
Vasoconstriction
English
We hypothesized that acute volume expansion by saline infusion triggers the release of endothelin-1. Bolus intravenous saline infusion (8 mL/min) in six groups of conscious Wistar rats and spontaneously hypertensive rats did not change mean arterial pressure or heart rate (n = 8 to 12). At 1 min after infusion, the plasma endothelin-1 level was significantly increased in Wistar rats and in spontaneously hypertensive rats by 42% and 61%, respectively (unpaired data). In 12 Wistar rats, the endothelin-1 level increased from 0.68 +/- 0.13 to 1.19 +/- 0.17 fmol/mL (mean +/- SEM, P <.0001, paired data). Thus, acute volume load by rapid saline infusion increases plasma endothelin-1 levels. Vasoconstriction induced by endothelin-1 may counteract enhanced circumferential stretch created by volume expansion.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1016/s0895-7061(03)01031-8
- PMID 14643582
- Persistent URL
- https://sonar.ch/global/documents/139232
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