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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
Journal article

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.

  • Martinon F Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.
  • Tschopp J
  • 2004-05-28
Published in:
  • Cell. - 2004
Animals
Apoptosis
Autoimmunity
Caspase Inhibitors
Caspases
Humans
Inflammation
Interleukin-1
Mice
Protein Structure, Tertiary
English Caspases not only play an essential role during apoptotic cell death, but a subfamily of them-the inflammatory caspases-are associated with immune responses to microbial pathogens. Activation of inflammatory caspases, such as caspase-1 and caspase-5, occurs upon assembly of an intracellular complex, designated the inflammasome. This results in the cleavage and activation of the proinflammatory cytokines IL-1beta and IL-18. Mutations in one of the scaffold proteins of the inflammasome, NALP3/Cryopyrin, are associated with autoinflammatory disorders underscoring the importance of regulating inflammatory caspase activation.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/139247
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