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Ubiquitylation and isgylation: overlapping enzymatic cascades do the job.
Journal article

Ubiquitylation and isgylation: overlapping enzymatic cascades do the job.

  • Staub O Department of Pharmacology and Toxicology, University of Lausanne, CH-1005 Lausanne, Switzerland. olivier.staub@ipharm.unil.ch
  • 2004-08-12
Published in:
  • Science's STKE : signal transduction knowledge environment. - 2004
Animals
Cytokines
Humans
Ubiquitin
Ubiquitin-Protein Ligase Complexes
Ubiquitins
English Ubiquitylation-that is, the covalent attachment of ubiquitin polypeptides to target proteins-involves the sequential action of the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. Similarly, the conjugation of ubiquitin-like proteins is thought to occur through parallel, but nonidentical, cascades. This concept of strict separation of these modification pathways is now being challenged by the evidence, showing that there are enzymes that play a role both in ubiquitylation and isgylation.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/139260
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