Back
Full-text
Journal article

Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence.

  • Harari A Laboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
  • Vallelian F
  • Meylan PR
  • Pantaleo G
  • 2005-01-07
Published in:
  • Journal of immunology (Baltimore, Md. : 1950). - 2005
Antigens
Antigens, Bacterial
Antigens, Viral
CD4-Positive T-Lymphocytes
Chronic Disease
Cytomegalovirus
Cytomegalovirus Infections
Disease Progression
Epitopes, T-Lymphocyte
HIV Infections
HIV-1
Herpesvirus 4, Human
Humans
Immunologic Memory
Immunophenotyping
Interleukin-2
Simplexvirus
Tetanus Toxoid
Virus Latency
English Memory CD4 T cell responses are functionally and phenotypically heterogeneous. In the present study, memory CD4 T cell responses were analyzed in different models of Ag-specific immune responses differing on Ag exposure and/or persistence. Ag-specific CD4 T cell responses for tetanus toxoid, HSV, EBV, CMV, and HIV-1 were compared. Three distinct patterns of T cell response were observed. A dominant single IL-2 CD4 T cell response was associated with the model in which the Ag can be cleared. Polyfunctional (single IL-2 plus IL-2/IFN-gamma plus single IFN-gamma) CD4 T cell responses were associated with Ag persistence and low Ag levels. A dominant single IFN-gamma CD4 T cell response was associated with the model of Ag persistence and high Ag levels. The results obtained supported the hypothesis that the different patterns observed were substantially influenced by different conditions of Ag exposure and persistence.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/139270
Statistics
Document views: 26 File downloads:
  • Full-text: 0