Journal article
In vitro evaluation of bronchodilator drug delivery by jet nebulization during pediatric mechanical ventilation.
- Di Paolo ER Department of Pharmacy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. Ermindo.Di-Paolo@chuv.hospvd.ch
- Pannatier A
- Cotting J
- 2005-06-29
Published in:
- Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. - 2005
Aerosols
Albuterol
Bronchodilator Agents
Humans
In Vitro Techniques
Infant
Nebulizers and Vaporizers
Particle Size
Respiration, Artificial
Technology Assessment, Biomedical
English
OBJECTIVE
To determine the influence of jet nebulizer brands and nebulization mode on albuterol delivery in a mechanically ventilated pediatric lung model.
DESIGN
In vitro, laboratory study.
SETTING
Research laboratory of a university hospital.
INTERVENTIONS
Using albuterol as a marker, six jet nebulizers (Microneb NA420, Sidestream, Acorn II, Cirrus, Upmist, Micro Mist) were tested in four nebulization modes in a bench model mimicking the ventilatory pattern of a 10-kg infant (Galileo ventilator, Hamilton Medical). The amounts of albuterol deposited on the inspiratory filters at the end of the endotracheal tube were determined, as well as the pressure, flow profiles, and particle size distribution of the jet nebulizers.
MEASUREMENTS AND MAIN RESULTS
Pooling the data of the six jet nebulizer brands (n = 30) indicated that intermittent nebulization during the expiratory phase was more efficient (6.5 +/- 2.5% of the initial dose, p < .001) than intermittent nebulization during the inspiratory phase (1.9 +/- 1.2%) and continuous nebulization with air from the ventilator (4.0 +/- 1.5%) or from an external source (4.2 +/- 1.4%). The particle size distribution at 6 L x min(-1) was between 2.81 and 3.30 microm.
CONCLUSIONS
In our in vitro pediatric lung model, the quantity of inhaled drug was low. Jet nebulizer brands and nebulization modes significantly affected drug delivery, and in vitro models designed for adults cannot be extrapolated to infants.
To determine the influence of jet nebulizer brands and nebulization mode on albuterol delivery in a mechanically ventilated pediatric lung model.
DESIGN
In vitro, laboratory study.
SETTING
Research laboratory of a university hospital.
INTERVENTIONS
Using albuterol as a marker, six jet nebulizers (Microneb NA420, Sidestream, Acorn II, Cirrus, Upmist, Micro Mist) were tested in four nebulization modes in a bench model mimicking the ventilatory pattern of a 10-kg infant (Galileo ventilator, Hamilton Medical). The amounts of albuterol deposited on the inspiratory filters at the end of the endotracheal tube were determined, as well as the pressure, flow profiles, and particle size distribution of the jet nebulizers.
MEASUREMENTS AND MAIN RESULTS
Pooling the data of the six jet nebulizer brands (n = 30) indicated that intermittent nebulization during the expiratory phase was more efficient (6.5 +/- 2.5% of the initial dose, p < .001) than intermittent nebulization during the inspiratory phase (1.9 +/- 1.2%) and continuous nebulization with air from the ventilator (4.0 +/- 1.5%) or from an external source (4.2 +/- 1.4%). The particle size distribution at 6 L x min(-1) was between 2.81 and 3.30 microm.
CONCLUSIONS
In our in vitro pediatric lung model, the quantity of inhaled drug was low. Jet nebulizer brands and nebulization modes significantly affected drug delivery, and in vitro models designed for adults cannot be extrapolated to infants.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1097/01.PCC.0000162452.68144.27
- PMID 15982436
- Persistent URL
- https://sonar.ch/global/documents/139318
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