Journal article
A missing sugar prevents glucose entry: a new twist on insulin secretion.
- Thorens B Department of Physiology and Center for Integrative Genomics, University of Lausanne, Genopode Building, CH-1015 Lausanne, Switzerland.
- 2006-01-10
Published in:
- Cell metabolism. - 2006
Animals
Galectins
Glucose
Glucose Transporter Type 2
Glycosylation
Humans
Insulin
Insulin Secretion
Mice
N-Acetylglucosaminyltransferases
English
The signaling pathway that regulates glucose-stimulated insulin secretion depends on glucose metabolism, which is itself controlled by glucokinase. In a recent issue of Cell, show that altering N-glycosylation of the GLUT2 glucose transporter prevents its anchoring and retention at the cell surface; this impairs glucose uptake and insulin secretion.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.cmet.2005.12.004
- PMID 16399498
- Persistent URL
- https://sonar.ch/global/documents/139356
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