High prevalence of side population in human cancer cell lines.
- Boesch M Institute of Immunobiology, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland.
- Zeimet AG Department of Gynecology and Obstetrics, Medical University of Innsbruck, 6020 Innsbruck, Austria.
- Fiegl H Department of Gynecology and Obstetrics, Medical University of Innsbruck, 6020 Innsbruck, Austria.
- Wolf B Department of Gynecology and Obstetrics, Medical University of Innsbruck, 6020 Innsbruck, Austria.
- Huber J Internal Medicine V, Medical University of Innsbruck, 6020 Innsbruck, Austria.
- Klocker H Department of Urology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
- Gastl G Internal Medicine V, Medical University of Innsbruck, 6020 Innsbruck, Austria.
- Sopper S Internal Medicine V, Medical University of Innsbruck, 6020 Innsbruck, Austria.
- Wolf D Medical Clinic III, University Clinic Bonn (UKB), 53127 Bonn, Germany.
- 2016-05-27
Published in:
- Oncoscience. - 2016
English
Cancer cell lines are essential platforms for performing cancer research on human cells. We here demonstrate that, across tumor entities, human cancer cell lines harbor minority populations of putative stem-like cells, molecularly defined by dye extrusion resulting in the side population phenotype. These findings establish a heterogeneous nature of human cancer cell lines and argue for their stem cell origin. This should be considered when interpreting research involving these model systems.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.18632/oncoscience.300
- PMID 27226981
- Persistent URL
- https://sonar.ch/global/documents/139762
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